0 47

Cited 0 times in

Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants

Authors
 Sang-Hoon Kim  ;  Jihye Kim  ;  Sungmin Jung  ;  Ji Yun Noh  ;  Jinnam Kim  ;  Heedo Park  ;  Young Goo Song  ;  Kyong Ran Peck  ;  Su-Hyung Park  ;  Man-Seong Park  ;  Jae-Hoon Ko  ;  Joon Young Song  ;  Jun Yong Choi  ;  Min Kyung Jung  ;  Eui-Cheol Shin 
Citation
 SCIENCE IMMUNOLOGY, Vol.9(91) : eade6132, 2024-01 
Journal Title
SCIENCE IMMUNOLOGY
Issue Date
2024-01
MeSH
BNT162 Vaccine* ; Breakthrough Infections ; CD8-Positive T-Lymphocytes* ; Epitopes, T-Lymphocyte ; Humans ; Peptides
Abstract
Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8+ T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8+ T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8+ T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8+ T cell responses that recognize epitopes within the spike of newly emerging subvariants.
Full Text
https://www.science.org/doi/10.1126/sciimmunol.ade6132
DOI
10.1126/sciimmunol.ade6132
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Nam(김진남)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198669
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links