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Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants

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dc.contributor.author송영구-
dc.contributor.author최준용-
dc.contributor.author김진남-
dc.date.accessioned2024-03-22T07:01:56Z-
dc.date.available2024-03-22T07:01:56Z-
dc.date.issued2024-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/198669-
dc.description.abstractHere, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8+ T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8+ T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8+ T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8+ T cell responses that recognize epitopes within the spike of newly emerging subvariants.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBNT162 Vaccine*-
dc.subject.MESHBreakthrough Infections-
dc.subject.MESHCD8-Positive T-Lymphocytes*-
dc.subject.MESHEpitopes, T-Lymphocyte-
dc.subject.MESHHumans-
dc.subject.MESHPeptides-
dc.titleOmicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSang-Hoon Kim-
dc.contributor.googleauthorJihye Kim-
dc.contributor.googleauthorSungmin Jung-
dc.contributor.googleauthorJi Yun Noh-
dc.contributor.googleauthorJinnam Kim-
dc.contributor.googleauthorHeedo Park-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorKyong Ran Peck-
dc.contributor.googleauthorSu-Hyung Park-
dc.contributor.googleauthorMan-Seong Park-
dc.contributor.googleauthorJae-Hoon Ko-
dc.contributor.googleauthorJoon Young Song-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorMin Kyung Jung-
dc.contributor.googleauthorEui-Cheol Shin-
dc.identifier.doi10.1126/sciimmunol.ade6132-
dc.contributor.localIdA02037-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ03772-
dc.identifier.eissn2470-9468-
dc.identifier.pmid38241400-
dc.identifier.urlhttps://www.science.org/doi/10.1126/sciimmunol.ade6132-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume9-
dc.citation.number91-
dc.citation.startPageeade6132-
dc.identifier.bibliographicCitationSCIENCE IMMUNOLOGY, Vol.9(91) : eade6132, 2024-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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