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Natal factors affecting developmental defects of enamel in preterm infants: a prospective cohort study

Authors
 Shang-Yon Park  ;  Su Jin Jeong  ;  Jung Ho Han  ;  Jeong Eun Shin  ;  Jae-Ho Lee  ;  Chung-Min Kang 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 2089, 2024-01 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-01
MeSH
Child ; Child, Preschool ; Developmental Defects of Enamel* ; Female ; Gestational Age ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Premature Birth* ; Prospective Studies
Abstract
This study investigated natal factors influencing developmental defects of enamel (DDE) in premature infants using a newly refined preterm developmental defects of enamel (PDDE) index. Dental examinations were conducted on a cohort of 118 preterm infants (average age 3.5 ± 1.4 years) to record PDDE scores, while reviewing their medical records to examine natal factors. According to the logistic regression analysis, factors related to DDE prevalence were advanced maternal age, gestational age < 28 weeks, birth weight < 1000 g, 1 min APGAR score < 7, and hospitalization period > 2 months, which were significantly higher by 2.91, 5.53, 7.63, 10.02, and 4.0 times, respectively. According to regression analysis with generalized linear models, the PDDE scores were approximately 7.65, 4.96, and 15.0 points higher in premature children diagnosed with bronchopulmonary dysplasia, intraventricular hemorrhage, and necrotizing enterocolitis, respectively. When endotracheal intubation was performed, the PDDE score was 5.06 points higher. The prevalence of PDDE was primarily observed bilaterally in the maxillary anterior teeth. Extremely preterm infants showed significantly delayed tooth eruption, suggesting that the influence of gestational age on dental development rates. Identifying the factors related to DDE in premature children can inform early dental interventions to support the oral health of high-risk children.
Files in This Item:
T202401025.pdf Download
DOI
10.1038/s41598-024-52525-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chung Min(강정민) ORCID logo https://orcid.org/0000-0001-7813-3741
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
Lee, Jae Ho(이제호) ORCID logo https://orcid.org/0000-0002-1556-3485
Han, Jung Ho(한정호) ORCID logo https://orcid.org/0000-0001-6661-8127
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198625
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