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Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats

 Kyeong-Mee Park  ;  Namkwon Lee  ;  Jaeyeon Kim  ;  Hyun Sil Kim  ;  Wonse Park 
 SCIENTIFIC REPORTS, Vol.13(1) : 15518, 2023-09 
Journal Title
Issue Date
Animals ; Female ; Osteonecrosis* / chemically induced ; Osteonecrosis* / prevention & control ; Rats ; Rats, Sprague-Dawley ; Teriparatide* / pharmacology ; X-Ray Microtomography ; Zoledronic Acid
This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction due to periodontal lesions in bilaterally ovariectomized female rats treated with zoledronic acid. Thirty skeletally mature Sprague-Dawley rats were randomly divided into three groups: control (CONT, n=10), zoledronic acid (ZA, n=10), and zoledronic acid and teriparatide (ZA-TPD, n=10). The rats were sacrificed 8 weeks after tooth extraction. Micro-computed tomography analysis of the tibia showed that bone mineral density was highest in the CONT, followed by that in the ZA and ZA-TPD groups (CONT/ZA, p=0.009; CONT/ZA-TPD, p<0.001; ZA/ZA-TPD, p<0.001). In the trabecular bone analysis of the extraction site, significant differences in specific bone surface (CONT/ZA, p=0.010; CONT/ZA-TPD, p=0.007; ZA/ZA-TPD, p=0.002) and trabecular thickness (CONT/ZA-TPD, p=0.002; ZA/ZA-TPD, p=0.002) were observed. Histological analyses of the extraction sites revealed characteristic MRONJ lesions in the ZA group. Osteonecrosis, inflammatory cells, and sequestrum were less frequently observed in the ZA-TPD group than in the ZA group. In conclusion, TPD administration before tooth extraction helped reduce the occurrence of MRONJ in rats treated with zoledronic acid, confirming its preventative effects.
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Park, Kyeong-Mee(박경미)
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
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