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Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats

Authors
 Kyeong-Mee Park  ;  Namkwon Lee  ;  Jaeyeon Kim  ;  Hyun Sil Kim  ;  Wonse Park 
Citation
 SCIENTIFIC REPORTS, Vol.13(1) : 15518, 2023-09 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2023-09
MeSH
Animals ; Female ; Osteonecrosis* / chemically induced ; Osteonecrosis* / prevention & control ; Rats ; Rats, Sprague-Dawley ; Teriparatide* / pharmacology ; X-Ray Microtomography ; Zoledronic Acid
Abstract
This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction due to periodontal lesions in bilaterally ovariectomized female rats treated with zoledronic acid. Thirty skeletally mature Sprague-Dawley rats were randomly divided into three groups: control (CONT, n=10), zoledronic acid (ZA, n=10), and zoledronic acid and teriparatide (ZA-TPD, n=10). The rats were sacrificed 8 weeks after tooth extraction. Micro-computed tomography analysis of the tibia showed that bone mineral density was highest in the CONT, followed by that in the ZA and ZA-TPD groups (CONT/ZA, p=0.009; CONT/ZA-TPD, p<0.001; ZA/ZA-TPD, p<0.001). In the trabecular bone analysis of the extraction site, significant differences in specific bone surface (CONT/ZA, p=0.010; CONT/ZA-TPD, p=0.007; ZA/ZA-TPD, p=0.002) and trabecular thickness (CONT/ZA-TPD, p=0.002; ZA/ZA-TPD, p=0.002) were observed. Histological analyses of the extraction sites revealed characteristic MRONJ lesions in the ZA group. Osteonecrosis, inflammatory cells, and sequestrum were less frequently observed in the ZA-TPD group than in the ZA group. In conclusion, TPD administration before tooth extraction helped reduce the occurrence of MRONJ in rats treated with zoledronic acid, confirming its preventative effects.
Files in This Item:
T202400760.pdf Download
DOI
10.1038/s41598-023-42607-y
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Park, Kyeong-Mee(박경미)
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198016
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