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Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats
DC Field | Value | Language |
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dc.contributor.author | 김현실 | - |
dc.contributor.author | 박원서 | - |
dc.contributor.author | 박경미 | - |
dc.date.accessioned | 2024-02-15T06:45:02Z | - |
dc.date.available | 2024-02-15T06:45:02Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198016 | - |
dc.description.abstract | This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction due to periodontal lesions in bilaterally ovariectomized female rats treated with zoledronic acid. Thirty skeletally mature Sprague-Dawley rats were randomly divided into three groups: control (CONT, n=10), zoledronic acid (ZA, n=10), and zoledronic acid and teriparatide (ZA-TPD, n=10). The rats were sacrificed 8 weeks after tooth extraction. Micro-computed tomography analysis of the tibia showed that bone mineral density was highest in the CONT, followed by that in the ZA and ZA-TPD groups (CONT/ZA, p=0.009; CONT/ZA-TPD, p<0.001; ZA/ZA-TPD, p<0.001). In the trabecular bone analysis of the extraction site, significant differences in specific bone surface (CONT/ZA, p=0.010; CONT/ZA-TPD, p=0.007; ZA/ZA-TPD, p=0.002) and trabecular thickness (CONT/ZA-TPD, p=0.002; ZA/ZA-TPD, p=0.002) were observed. Histological analyses of the extraction sites revealed characteristic MRONJ lesions in the ZA group. Osteonecrosis, inflammatory cells, and sequestrum were less frequently observed in the ZA-TPD group than in the ZA group. In conclusion, TPD administration before tooth extraction helped reduce the occurrence of MRONJ in rats treated with zoledronic acid, confirming its preventative effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Osteonecrosis* / chemically induced | - |
dc.subject.MESH | Osteonecrosis* / prevention & control | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Teriparatide* / pharmacology | - |
dc.subject.MESH | X-Ray Microtomography | - |
dc.subject.MESH | Zoledronic Acid | - |
dc.title | Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학교실) | - |
dc.contributor.googleauthor | Kyeong-Mee Park | - |
dc.contributor.googleauthor | Namkwon Lee | - |
dc.contributor.googleauthor | Jaeyeon Kim | - |
dc.contributor.googleauthor | Hyun Sil Kim | - |
dc.contributor.googleauthor | Wonse Park | - |
dc.identifier.doi | 10.1038/s41598-023-42607-y | - |
dc.contributor.localId | A01121 | - |
dc.contributor.localId | A01589 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 37726385 | - |
dc.contributor.alternativeName | Kim, Hyun Sil | - |
dc.contributor.affiliatedAuthor | 김현실 | - |
dc.contributor.affiliatedAuthor | 박원서 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15518 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 15518, 2023-09 | - |
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