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Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women

Authors
 Chaewon Lee  ;  Hye-Sun Park  ;  Yumie Rhee  ;  Namki Hong 
Citation
 Endocrinology and Metabolism (대한내분비학회지), Vol.38(6) : 669-678, 2023-12 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
ISSN
 2093-596X 
Issue Date
2023-12
MeSH
Aged ; Female ; Fractures, Bone* / epidemiology ; Fractures, Bone* / etiology ; Humans ; Middle Aged ; Postmenopause* ; Republic of Korea / epidemiology
Keywords
Body height ; Cohort studies ; Fractures, bone
Abstract
Background: Height loss is a simple clinical measure associated with increased fracture risk. However, limited data exists on the association

between height loss and fracture risk in postmenopausal Korean women. It is unknown whether this association varies with

age.

Methods: Data on height loss over a 6-year period were collected from a community-based longitudinal follow-up cohort (Ansung

cohort of the Korean Genome and Epidemiology Study). Incident fractures were defined based on self-reported fractures after excluding

those due to severe trauma or toes/fingers. The association between incident fractures and height loss was investigated using

a Cox proportional hazards model.

Results: During a median follow-up of 10 years after the second visit, 259/1,806 participants (median age, 64 years) experienced incident

fractures. Overall, a 1 standard deviation (SD) decrease in height (1.6 cm/median 5.8 years) was associated with 9% increased

risk of fracture (hazard ratio [HR], 1.09; P=0.037), which lost statistical significance after adjustment for covariates. When stratified

into age groups (50–59, 60–69, 70 years or older), a 1 SD decrease in height remained a robust predictor of fracture in the 50 to 59

years age group after adjusting for covariates (adjusted hazard ratio [aHR], 1.52; P=0.003), whereas height loss was not an independent

predictor of fracture in the 60 to 69 (aHR, 1.06; P=0.333) or the 70 years or older age groups (aHR, 1.05; P=0.700; P for interaction

<0.05, for all).

Conclusion: Height loss during the previous 6 years was associated with an increased 10-year fracture risk in postmenopausal women

in their 50s.
Files in This Item:
T202400293.pdf Download
DOI
10.3803/EnM.2023.1734
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hye Sun(박혜선)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197868
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