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Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women
DC Field | Value | Language |
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dc.contributor.author | 박혜선 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2024-01-31T05:44:26Z | - |
dc.date.available | 2024-01-31T05:44:26Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197868 | - |
dc.description.abstract | Background: Height loss is a simple clinical measure associated with increased fracture risk. However, limited data exists on the association between height loss and fracture risk in postmenopausal Korean women. It is unknown whether this association varies with age. Methods: Data on height loss over a 6-year period were collected from a community-based longitudinal follow-up cohort (Ansung cohort of the Korean Genome and Epidemiology Study). Incident fractures were defined based on self-reported fractures after excluding those due to severe trauma or toes/fingers. The association between incident fractures and height loss was investigated using a Cox proportional hazards model. Results: During a median follow-up of 10 years after the second visit, 259/1,806 participants (median age, 64 years) experienced incident fractures. Overall, a 1 standard deviation (SD) decrease in height (1.6 cm/median 5.8 years) was associated with 9% increased risk of fracture (hazard ratio [HR], 1.09; P=0.037), which lost statistical significance after adjustment for covariates. When stratified into age groups (50–59, 60–69, 70 years or older), a 1 SD decrease in height remained a robust predictor of fracture in the 50 to 59 years age group after adjusting for covariates (adjusted hazard ratio [aHR], 1.52; P=0.003), whereas height loss was not an independent predictor of fracture in the 60 to 69 (aHR, 1.06; P=0.333) or the 70 years or older age groups (aHR, 1.05; P=0.700; P for interaction <0.05, for all). Conclusion: Height loss during the previous 6 years was associated with an increased 10-year fracture risk in postmenopausal women in their 50s. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Endocrine Society | - |
dc.relation.isPartOf | Endocrinology and Metabolism(대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fractures, Bone* / epidemiology | - |
dc.subject.MESH | Fractures, Bone* / etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postmenopause* | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.title | Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chaewon Lee | - |
dc.contributor.googleauthor | Hye-Sun Park | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.identifier.doi | 10.3803/EnM.2023.1734 | - |
dc.contributor.localId | A01761 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J00773 | - |
dc.identifier.eissn | 2093-5978 | - |
dc.identifier.pmid | 37652869 | - |
dc.subject.keyword | Body height | - |
dc.subject.keyword | Cohort studies | - |
dc.subject.keyword | Fractures, bone | - |
dc.contributor.alternativeName | Park, Hye Sun | - |
dc.contributor.affiliatedAuthor | 박혜선 | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 669 | - |
dc.citation.endPage | 678 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism(대한내분비학회지), Vol.38(6) : 669-678, 2023-12 | - |
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