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Fat Biology in Triple-Negative Breast Cancer: Immune Regulation, Fibrosis, and Senescence

Authors
 Chae Min Lee  ;  Sungsoon Fang 
Citation
 JOURNAL OF OBESITY & METABOLIC SYNDROME, Vol.32(4) : 312-321, 2023-12 
Journal Title
JOURNAL OF OBESITY & METABOLIC SYNDROME
ISSN
 2508-6235 
Issue Date
2023-12
Keywords
Fibrosis ; Immunity ; Obesity ; Senescence ; Triple-negative breast cancer ; Tumor microenvironment
Abstract
Obesity, now officially recognized as a disease requiring intervention, has emerged as a significant health concern due to its strong association with elevated susceptibility to diverse diseases and various types of cancer, including breast cancer. The link between obesity and cancer is intricate, with obesity exerting a significant impact on cancer recurrence and elevated mortality rates. Among the various subtypes of breast cancer, triple-negative breast cancer (TNBC) is the most aggressive, accounting for 15% to 20% of all cases. TNBC is characterized by low expression of estrogen receptors and progesterone receptors as well as the human epidermal growth factor 2 receptor protein. This subtype poses distinct challenges in terms of treatment response and exhibits strong invasiveness. Furthermore, TNBC has garnered attention because of its association with obesity, in which excess body fat and reduced physical activity have been identified as contributing factors to the increased incidence of this aggressive form of breast cancer. In this comprehensive review, the impact of obesity on TNBC was explored. Specifically, we focused on the three key mechanisms by which obesity affects TNBC development and progression: modification of the immune profile, facilitation of fibrosis, and initiation of senescence. By comprehensively examining these mechanisms, we illuminated the complex interplay between TNBC and obesity, facilitating the development of novel approaches for prevention, early detection, and effective management of this challenging disease.
Files in This Item:
T202400077.pdf Download
DOI
10.7570/jomes23044
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Fang, Sungsoon(황성순) ORCID logo https://orcid.org/0000-0003-0201-5567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197818
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