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Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease

Authors
 Ji Yeon Choi  ;  Bora Shim  ;  Youngmok Park  ;  Young Ae Kang 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.38(6) : 879-892, 2023-11 
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
ISSN
 1226-3303 
Issue Date
2023-11
MeSH
Gastrointestinal Microbiome* ; Humans ; Lung ; Lung Diseases* ; Mycobacterium Infections, Nontuberculous* / diagnosis ; Mycobacterium Infections, Nontuberculous* / epidemiology ; Nontuberculous Mycobacteria / genetics ; RNA, Ribosomal, 16S / genetics
Keywords
Gastrointestinal microbiome ; Lungs ; Microbiota ; Nontuberculous mycobacteria
Abstract
Background/aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.

Methods: We analyzed the microbiota diversity in sputum and stool samples from 10 healthy subjects and 10 patients with NTM-PD through sequencing of the V3 and V4 regions of the 16S rRNA gene. In NTM-PD patients, we comparatively evaluated the microbiota diversity according to the body mass index (BMI), with BMI ≤ 18.5 kg/m2 defined as "underweight" and BMI > 18.5 kg/m2 as "others."

Results: The sputum microbiota from NTM-PD patients tended to have lower index values of amplicon sequence variant richness, Shannon evenness, and beta diversity than those from the control group. Furthermore, NTM-PD patients with a low BMI had a lower microbiota diversity than patients with high BMI. Fecal samples from NTM-PD patients also significantly differed in alpha and beta diversity compared with the control group and exhibited a diversity pattern similar to that found in sputum samples.

Conclusion: Our results reveal that the lung and gut microbiota of patients with NTM-PD exhibit an altered distribution and reduced richness and diversity.
Files in This Item:
T202307088.pdf Download
DOI
10.3904/kjim.2023.097
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197647
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