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Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 박영목 | - |
dc.date.accessioned | 2024-01-03T01:44:51Z | - |
dc.date.available | 2024-01-03T01:44:51Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197647 | - |
dc.description.abstract | Background/aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study. Methods: We analyzed the microbiota diversity in sputum and stool samples from 10 healthy subjects and 10 patients with NTM-PD through sequencing of the V3 and V4 regions of the 16S rRNA gene. In NTM-PD patients, we comparatively evaluated the microbiota diversity according to the body mass index (BMI), with BMI ≤ 18.5 kg/m2 defined as "underweight" and BMI > 18.5 kg/m2 as "others." Results: The sputum microbiota from NTM-PD patients tended to have lower index values of amplicon sequence variant richness, Shannon evenness, and beta diversity than those from the control group. Furthermore, NTM-PD patients with a low BMI had a lower microbiota diversity than patients with high BMI. Fecal samples from NTM-PD patients also significantly differed in alpha and beta diversity compared with the control group and exhibited a diversity pattern similar to that found in sputum samples. Conclusion: Our results reveal that the lung and gut microbiota of patients with NTM-PD exhibit an altered distribution and reduced richness and diversity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Association of Internal Medicine | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Gastrointestinal Microbiome* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung | - |
dc.subject.MESH | Lung Diseases* | - |
dc.subject.MESH | Mycobacterium Infections, Nontuberculous* / diagnosis | - |
dc.subject.MESH | Mycobacterium Infections, Nontuberculous* / epidemiology | - |
dc.subject.MESH | Nontuberculous Mycobacteria / genetics | - |
dc.subject.MESH | RNA, Ribosomal, 16S / genetics | - |
dc.title | Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ji Yeon Choi | - |
dc.contributor.googleauthor | Bora Shim | - |
dc.contributor.googleauthor | Youngmok Park | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.3904/kjim.2023.097 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A05828 | - |
dc.relation.journalcode | J02883 | - |
dc.identifier.eissn | 2005-6648 | - |
dc.identifier.pmid | 37867139 | - |
dc.subject.keyword | Gastrointestinal microbiome | - |
dc.subject.keyword | Lungs | - |
dc.subject.keyword | Microbiota | - |
dc.subject.keyword | Nontuberculous mycobacteria | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.contributor.affiliatedAuthor | 박영목 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 879 | - |
dc.citation.endPage | 892 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.38(6) : 879-892, 2023-11 | - |
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