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Prognostic value of functional tricuspid regurgitation quantified by cardiac magnetic resonance in heart failure

Authors
 Jiwon Seo  ;  Yoo Jin Hong  ;  Uuganbayar Batbayar  ;  Dae-Young Kim  ;  Iksung Cho  ;  Young-Jin Kim  ;  Geu-Ru Hong  ;  Jong-Won Ha  ;  Chi Young Shim 
Citation
 EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol.24(6) : 742-750, 2023-05 
Journal Title
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
ISSN
 2047-2404 
Issue Date
2023-05
MeSH
Heart Failure* ; Humans ; Magnetic Resonance Spectroscopy ; Prognosis ; Risk Factors ; Stroke Volume ; Tricuspid Valve Insufficiency* / surgery ; Ventricular Dysfunction, Left*
Keywords
heart failure ; magnetic resonance ; renal function ; tricuspid regurgitation
Abstract
Aims: Quantitative assessment of tricuspid regurgitation (TR) is challenging, and the prognostic implications of cardiac magnetic resonance (CMR)-quantified measures of TR remain unclear in patients with heart failure with reduced ejection fraction (HFrEF). This study investigated the prognostic value of functional TR quantified by CMR in patients with HFrEF.

Methods and results: A total of 262 patients with HFrEF who underwent CMR were analysed. Patients who had primary TR, who had acute HF, or for whom cardiac surgery was planned were excluded. TR volume and fraction were indirectly calculated via subtracting methods. The primary outcome was defined as a composite of all-cause death and hospitalization for HF. Renal outcome was defined as a composite of a decrease in estimated glomerular filtration rate ≥50% or progression to end-stage renal disease. During the follow-up period (median 921 days), 62 primary outcomes and 48 renal outcomes occurred. When divided into two or three groups based on TR fraction in Kaplan-Meier analysis, patients with higher TR fractions showed worse primary outcomes and renal outcomes than those with lower TR fractions. In Cox regression analysis, a 10% increase in TR fraction was significantly associated with primary outcome [hazard ratio (HR) 1.49, 95% confidence interval (CI) 1.29-1.73, P < 0.001] and renal outcome (HR 1.31, 95% CI 1.12-1.55, P = 0.001). TR fraction exhibited a strong positive linear relationship with primary outcomes and renal outcomes in restricted cubic spline curves.

Conclusion: CMR-quantified measures of TR were independently associated with adverse clinical outcomes in patients with HFrEF.
Full Text
https://academic.oup.com/ehjcimaging/article/24/6/742/6832117
DOI
10.1093/ehjci/jeac224
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae-Young(김대영)
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Seo, Jiwon(서지원) ORCID logo https://orcid.org/0000-0002-7641-3739
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Cho, Ik Sung(조익성)
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197315
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