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Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson's disease

Authors
 Seong Ho Jeong  ;  Chae Jung Park  ;  Hyun-Jae Jeong  ;  Mun Kyung Sunwoo  ;  Sung Soo Ahn  ;  Seung-Koo Lee  ;  Phil Hyu Lee  ;  Yun Joong Kim  ;  Young Ho Sohn  ;  Seok Jong Chung 
Citation
 JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.94(12) : 1047-1055, 2023-12 
Journal Title
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
ISSN
 0022-3050 
Issue Date
2023-12
MeSH
Choroid Plexus / diagnostic imaging ; Choroid Plexus / metabolism ; Corpus Striatum / metabolism ; Dopamine / metabolism ; Dopamine / therapeutic use ; Dopamine Plasma Membrane Transport Proteins / metabolism ; Gait Disorders, Neurologic* / diagnostic imaging ; Gait Disorders, Neurologic* / etiology ; Gait Disorders, Neurologic* / metabolism ; Humans ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging ; Parkinson Disease* / drug therapy ; Retrospective Studies
Keywords
MRI ; PARKINSON'S DISEASE ; PET ; FUNCTIONAL IMAGING
Abstract
Background: The choroid plexus (CP) is involved in the clearance of harmful metabolites from the brain, as a part of the glymphatic system. This study aimed to investigate the association between CP volume (CPV), nigrostriatal dopaminergic degeneration and motor outcomes in Parkinson's disease (PD).

Methods: We retrospectively searched drug-naïve patients with early-stage PD who underwent dopamine transporter (DAT) scanning and MRI. Automatic CP segmentation was performed, and the CPV was calculated. The relationship between CPV, DAT availability and Unified PD Rating Scale Part III (UPDRS-III) scores was assessed using multivariate linear regression. We performed longitudinal analyses to assess motor outcomes according to CPV.

Results: CPV was negatively associated with DAT availability in each striatal subregion (anterior caudate, β=-0.134, p=0.012; posterior caudate, β=-0.162, p=0.002; anterior putamen, β=-0.133, p=0.024; posterior putamen, β=-0.125, p=0.039; ventral putamen, β=-0.125, p=0.035), except for the ventral striatum. CPV was positively associated with the UPDRS-III score even after adjusting for DAT availability in the posterior putamen (β=0.121; p=0.035). A larger CPV was associated with the future development of freezing of gait in the Cox regression model (HR 1.539, p=0.027) and a more rapid increase in dopaminergic medication in the linear mixed model (CPV×time, p=0.037), but was not associated with the risk of developing levodopa-induced dyskinesia or wearing off.

Conclusion: These findings suggest that CPV has the potential to serve as a biomarker for baseline and longitudinal motor disabilities in PD.
Full Text
https://jnnp.bmj.com/content/94/12/1047.long
DOI
10.1136/jnnp-2023-331170
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yun Joong(김윤중) ORCID logo https://orcid.org/0000-0002-2956-1552
Park, Chae Jung(박채정) ORCID logo https://orcid.org/0000-0002-5567-8658
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196859
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