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Polo-like Kinase 4: A Multifaceted Marker Linking Tumor Aggressiveness and Unfavorable Prognosis, and Insights into Therapeutic Strategies

Authors
 Youngtaek Kim  ;  Joon Yeon Hwang  ;  Dong Kwon Kim  ;  Kwangmin Na  ;  Seul Lee  ;  Sujeong Baek  ;  Seong-San Kang  ;  Seung Min Yang  ;  Mi Hyun Kim  ;  Heekyung Han  ;  Chai Young Lee  ;  Yu Jin Han  ;  Min Hee Hong  ;  Jii Bum Lee  ;  Sun Min Lim  ;  Byoung Chul Cho  ;  Youngjoon Park  ;  Kyoung-Ho Pyo 
Citation
 CANCERS, Vol.15(18) : 4663, 2023-09 
Journal Title
CANCERS
Issue Date
2023-09
Keywords
PLK4 ; TP53 ; biomarkers ; drug resistance ; lung adenocarcinoma
Abstract
(1) Background: This study investigated whether polo-like kinase 4 (PLK4) is a suitable therapeutic target or biomarker for lung adenocarcinoma (LUAD).

(2) Methods: We acquired LUAD data from The Cancer Genome Atlas (TCGA) database through the UCSC Xena data portal. Gene expression, clinical, survival, and mutation data from multiple samples were analyzed. Gene enrichment analysis, unsupervised clustering of PLK4-related pathways, and differential gene expression analyses were performed. Additionally, correlations, t-tests, survival analyses, and statistical analyses were performed.

(3) Results: PLK4 expression was higher in LUAD tissues than in normal tissues and was associated with poor prognosis for both overall and progression-free survival in LUAD. PLK4 was highly correlated with cell-proliferation-related pathways using Gene Ontology (GO) biological process terms. PLK4 expression and pathways that were highly correlated with PLK4 expression levels were upregulated in patients with LUAD with the TP53 mutation.

(4) Conclusions: PLK4 expression affects the survival of patients with LUAD and is a potential therapeutic target for LUAD with TP53 mutations.
Files in This Item:
T202306447.pdf Download
DOI
10.3390/cancers15184663
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, YoungJoon(박영준)
Lee, Jii Bum(이기쁨) ORCID logo https://orcid.org/0000-0001-5608-3157
Lim, Sun Min(임선민)
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
Pyo, Kyoung Ho(표경호) ORCID logo https://orcid.org/0000-0001-5428-0288
Hong, Min Hee(홍민희) ORCID logo https://orcid.org/0000-0003-3490-2195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196851
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