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Polo-like Kinase 4: A Multifaceted Marker Linking Tumor Aggressiveness and Unfavorable Prognosis, and Insights into Therapeutic Strategies
DC Field | Value | Language |
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dc.contributor.author | 이기쁨 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 표경호 | - |
dc.contributor.author | 홍민희 | - |
dc.contributor.author | 박영준 | - |
dc.date.accessioned | 2023-11-28T03:33:06Z | - |
dc.date.available | 2023-11-28T03:33:06Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196851 | - |
dc.description.abstract | (1) Background: This study investigated whether polo-like kinase 4 (PLK4) is a suitable therapeutic target or biomarker for lung adenocarcinoma (LUAD). (2) Methods: We acquired LUAD data from The Cancer Genome Atlas (TCGA) database through the UCSC Xena data portal. Gene expression, clinical, survival, and mutation data from multiple samples were analyzed. Gene enrichment analysis, unsupervised clustering of PLK4-related pathways, and differential gene expression analyses were performed. Additionally, correlations, t-tests, survival analyses, and statistical analyses were performed. (3) Results: PLK4 expression was higher in LUAD tissues than in normal tissues and was associated with poor prognosis for both overall and progression-free survival in LUAD. PLK4 was highly correlated with cell-proliferation-related pathways using Gene Ontology (GO) biological process terms. PLK4 expression and pathways that were highly correlated with PLK4 expression levels were upregulated in patients with LUAD with the TP53 mutation. (4) Conclusions: PLK4 expression affects the survival of patients with LUAD and is a potential therapeutic target for LUAD with TP53 mutations. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Polo-like Kinase 4: A Multifaceted Marker Linking Tumor Aggressiveness and Unfavorable Prognosis, and Insights into Therapeutic Strategies | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Youngtaek Kim | - |
dc.contributor.googleauthor | Joon Yeon Hwang | - |
dc.contributor.googleauthor | Dong Kwon Kim | - |
dc.contributor.googleauthor | Kwangmin Na | - |
dc.contributor.googleauthor | Seul Lee | - |
dc.contributor.googleauthor | Sujeong Baek | - |
dc.contributor.googleauthor | Seong-San Kang | - |
dc.contributor.googleauthor | Seung Min Yang | - |
dc.contributor.googleauthor | Mi Hyun Kim | - |
dc.contributor.googleauthor | Heekyung Han | - |
dc.contributor.googleauthor | Chai Young Lee | - |
dc.contributor.googleauthor | Yu Jin Han | - |
dc.contributor.googleauthor | Min Hee Hong | - |
dc.contributor.googleauthor | Jii Bum Lee | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Youngjoon Park | - |
dc.contributor.googleauthor | Kyoung-Ho Pyo | - |
dc.identifier.doi | 10.3390/cancers15184663 | - |
dc.contributor.localId | A05930 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A04809 | - |
dc.contributor.localId | A04393 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 37760631 | - |
dc.subject.keyword | PLK4 | - |
dc.subject.keyword | TP53 | - |
dc.subject.keyword | biomarkers | - |
dc.subject.keyword | drug resistance | - |
dc.subject.keyword | lung adenocarcinoma | - |
dc.contributor.alternativeName | Lee, Jii Bum | - |
dc.contributor.affiliatedAuthor | 이기쁨 | - |
dc.contributor.affiliatedAuthor | 임선민 | - |
dc.contributor.affiliatedAuthor | 조병철 | - |
dc.contributor.affiliatedAuthor | 표경호 | - |
dc.contributor.affiliatedAuthor | 홍민희 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 4663 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.15(18) : 4663, 2023-09 | - |
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