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Surfactant-like photosensitizer for endoscopic duodenal ablation: Modulating meal-stimulated incretin hormones in obese and type 2 diabetes

Authors
 Sanghee Lee  ;  Moon Jae Chung  ;  Minji Ahn  ;  Hyun Jin Park  ;  Eun Kyung Wang  ;  Taeeun Guon  ;  Hyun Jung Kee  ;  Cheol Ryong Ku  ;  Kun Na 
Citation
 BIOMATERIALS, Vol.302 : 122336, 2023-11 
Journal Title
BIOMATERIALS
ISSN
 0142-9612 
Issue Date
2023-11
Keywords
Duodenal mucosal resurfacing ; Incretin hormones ; Obesity ; Photodynamic therapy ; Surfactant like photosensitizer
Abstract
Duodenal ablation improves glycaemic control and weight loss, so it has been applied using hydrothermal catheters in obese and type 2 diabetes patients, indicating similar mechanisms and therapeutic effects as bariatric surgeries. Endoscopic photodynamic therapy is an innovative procedure that easily accessible to endocrine or gastrointestinal organs, so it is critical for the sprayed photosensitizer (PS) to long-term interact with target tissues for enhancing its effects. Surfactant-like PS was more stable in a wide range of pH and 2.8-fold more retained in the duodenum at 1 h than hydrophilic PS due to its amphiphilic property. Endoscopic duodenal ablation using surfactant-like PS was performed in high fat diet induced rat models, demonstrating body weight loss, enhanced insulin sensitivity, and modulation of incretin hormones. Locoregional ablation of duodenum could affect the profiles of overall intestinal cells secreting meal-stimulated hormones and further the systemic glucose and lipid metabolism, regarding gut-brain axis. Our strategy suggests a potential for a treatment of minimally invasive bariatric and metabolic therapy if accompanied by detailed clinical trials.
Full Text
https://www.sciencedirect.com/science/article/pii/S0142961223003447
DOI
10.1016/j.biomaterials.2023.122336
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Cheol Ryong(구철룡) ORCID logo https://orcid.org/0000-0001-8693-9630
Kee, Hyun Jung(기현정) ORCID logo https://orcid.org/0000-0003-4350-1852
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196628
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