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Gene signature from cutaneous autoimmune diseases provides potential immunotherapy-relevant biomarkers in melanoma

 Kyu-Hye Chun  ;  Ye-Chan Park  ;  Nahee Hwang  ;  Bo Kyung Yoon  ;  Jae-Woo Kim  ;  Sungsoon Fang 
 SCIENTIFIC REPORTS, Vol.13(1) : 15023, 2023-09 
Journal Title
Issue Date
Autoimmune Diseases* / genetics ; Autoimmune Diseases* / therapy ; Biomarkers ; Dermatitis, Atopic* ; Humans ; Immune Checkpoint Inhibitors / pharmacology ; Immune Checkpoint Inhibitors / therapeutic use ; Immunotherapy ; Lupus Erythematosus, Systemic* ; Melanoma* / genetics ; Melanoma* / therapy ; Psoriasis* ; Skin Diseases*
Immune checkpoint inhibitors (ICIs) are promising agents for treating melanoma. Given that autoimmune skin diseases exhibit hyper immune reaction, investigation of immune cells from autoimmune skin disease is crucial to validate the effectiveness of ICIs in melanoma treatment. We employed multipanel markers to predict the response to immune checkpoint inhibitors by characterizing the gene expression signatures of skin immune cells in systemic lupus erythematosus (SLE), atopic dermatitis (AD), and psoriasis (PS). By analyzing single-cell RNA sequencing data from each dataset, T cell gene signatures from autoimmune skin diseases exhibit a complex immune response in tumors that responded to immunotherapy. Based on that CD86 and CD80 provide essential costimulatory signals for T cell activation, we observed that interaction of CD86 signaling has been enhanced in the T cells of patients with SLE, AD, and PS. Our analysis revealed a common increase in CD86 signals from dendritic cells (DCs) to T cells in patients with SLE, AD, and PS, confirming that dendritic cells produce pro-inflammatory cytokines to activate T cells. Thus, we hypothesize that T cell gene signatures from autoimmune skin diseases exhibit a pro-inflammatory response and have the potential to predict cancer immunotherapy. Our study demonstrated that T cell gene signatures derived from inflammatory skin diseases, particularly SLE and PS, hold promise as potential biomarkers for predicting the response to immune checkpoint blockade therapy in patients with melanoma. Our data provide an understanding of the immune-related characteristics and differential gene expression patterns in autoimmune skin diseases, which may represent promising targets for melanoma immunotherapy.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Woo(김재우) ORCID logo https://orcid.org/0000-0001-5456-9495
Yoon, Bo Kyung(윤보경)
Fang, Sungsoon(황성순) ORCID logo https://orcid.org/0000-0003-0201-5567
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