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Association between choroid plexus volume and cognition in Parkinson disease

 Seong Ho Jeong  ;  Hyun-Jae Jeong  ;  Mun Kyung Sunwoo  ;  Sung Soo Ahn  ;  Seung-Koo Lee  ;  Phil Hyu Lee  ;  Yun Joong Kim  ;  Young H Sohn  ;  Chae Jung Park  ;  Seok Jong Chung 
 EUROPEAN JOURNAL OF NEUROLOGY, Vol.30(10) : 3114-3123, 2023-10 
Journal Title
Issue Date
Choroid Plexus / diagnostic imaging ; Cognition / physiology ; Cognitive Dysfunction* / complications ; Cognitive Dysfunction* / etiology ; Dementia* / complications ; Dementia* / etiology ; Humans ; Magnetic Resonance Imaging / methods ; Neuropsychological Tests ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging ; Parkinson Disease* / psychology ; Retrospective Studies
Parkinson disease ; choroid plexus ; cognition ; dementia
Background and purpose: The choroid plexus (CP) clears harmful metabolites from the central nervous system as part of the glymphatic system. We investigated the association of CP volume (CPV) with baseline and longitudinal cognitive decline in patients with Parkinson disease (PD).

Methods: We retrospectively reviewed the medical records of 240 patients with newly diagnosed PD who had undergone detailed neuropsychological tests and high-resolution T1-weighted structural magnetic resonance imaging during the initial assessment. The CPV of each patient was automatically segmented, and the intracranial volume ratio was used in subsequent analyses. The relationship between CPV and baseline composite scores of each cognitive domain was assessed using multivariate linear regression analyses. A Cox proportional hazards model was used to compare the risk of dementia conversion with CPV.

Results: CPV negatively correlated with composite scores of the frontal/executive function domain (β = -0.375, p = 0.002) after adjusting for age, sex, years of education, and parkinsonian symptom duration. The Cox regression model revealed that a larger CPV was associated with a higher risk of dementia conversion (hazard ratio [HR] = 1.509, p = 0.038), which was no longer significant after adjusting for the composite scores of the frontal/executive function domain. A mediation analysis demonstrated that the effect of CPV on the risk of dementia conversion was completely mediated by frontal/executive function (direct effect: HR = 1.203, p = 0.396; indirect effect: HR = 1.400, p = 0.015).

Conclusions: Baseline CPV is associated with baseline frontal/executive function, which subsequently influences dementia conversion risk in patients with PD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yun Joong(김윤중) ORCID logo https://orcid.org/0000-0002-2956-1552
Park, Chae Jung(박채정) ORCID logo https://orcid.org/0000-0002-5567-8658
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
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