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Polycyclic aromatic hydrocarbons and changes in brain cortical thickness and an Alzheimer's disease-specific marker for cortical atrophy in adults: A longitudinal neuroimaging study of the EPINEF cohort

Authors
 Jaelim Cho  ;  Jungwoo Sohn  ;  Sung Hee Yang  ;  Seung-Koo Lee  ;  Young Noh  ;  Sung Soo Oh  ;  Sang-Baek Koh  ;  Changsoo Kim 
Citation
 CHEMOSPHERE, Vol.338 : 139596, 2023-10 
Journal Title
CHEMOSPHERE
ISSN
 0045-6535 
Issue Date
2023-10
MeSH
Adult ; Alzheimer Disease* ; Atrophy ; Biomarkers / urine ; Brain Cortical Thickness ; Humans ; Neuroimaging ; Polycyclic Aromatic Hydrocarbons* / metabolism
Keywords
Cortical thickness ; Linear mixed model ; Neuroimaging ; Polycyclic aromatic hydrocarbon
Abstract
Although several epidemiological studies have suggested that exposure to polycyclic aromatic hydrocarbons (PAHs) may induce brain atrophy, no longitudinal study has investigated the effect of PAH exposure on brain structural changes. This study examined the longitudinal associations between urinary PAH metabolites and brain cortical thickness. We obtained urinary concentrations of PAH metabolites and brain magnetic resonance images from 327 adults (≥50 years of age) without dementia at baseline and 3-year follow-up. We obtained whole-brain and regional cortical thicknesses, as well as an Alzheimer's disease (AD)-specific marker for cortical atrophy (a higher score indicated a greater similarity to patients with AD) at baseline and follow-up. We built a linear mixed-effect model including each of urinary PAH metabolites as the time-varying exposure variable of interest. We found that increases in urinary concentrations of 1-hydroxypyrene (β = −0.004; 95% CI, −0.008 to −0.001) and 2-hydroxyfluorene (β = −0.011; 95% CI, −0.015 to −0.006) were significantly associated with a reduced whole-brain cortical thickness. A urinary concentration of 2-hydroxyfluorene was significantly associated with an increased AD-specific cortical atrophy score (β = 2.031; 95% CI, 0.512 to 3.550). The specific brain regions showing the association of urinary concentrations of 1-hydroxypyrene, 2-naphthol, 1-hydroxyphenanthrene, or 2-hydroxyfluorene with cortical thinning were the frontal, parietal, temporal, and cingulate lobes. These findings suggested that exposure to PAHs may reduce brain cortical thickness and increase the similarity to AD-specific cortical atrophy patterns in adults. © 2023 Elsevier Ltd
Full Text
https://www.sciencedirect.com/science/article/pii/S0045653523018635
DOI
10.1016/j.chemosphere.2023.139596
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196357
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