Cited 4 times in

Delivery of recombinant sestrin2 ameliorates oxidative stress, mitochondrial damage and renal dysfunction in contrast-induced acute kidney injury

DC Field Value Language
dc.contributor.author배희진-
dc.contributor.author유제성-
dc.contributor.author정용은-
dc.date.accessioned2023-10-19T05:58:01Z-
dc.date.available2023-10-19T05:58:01Z-
dc.date.issued2023-09-
dc.identifier.issn0006-2952-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196313-
dc.description.abstractAlthough the use of iodinated contrast agents is sometimes unavoidable for accurate diagnosis, contrast-induced acute kidney injury (CI-AKI) is a possible complication of its administration. The pathogenesis of CI-AKI has not been fully elucidated, but oxidative stress is thought to be a major factor. Sestrin2 plays an important role in cellular and mitochondrial homeostasis by regulating oxidative stress. In this study, we aimed to investigate whether recombinant adenovirus containing sestrin2 (RS) can attenuate CI-AKI by reducing oxidative stress in a CI-AKI mice model. Our results showed that RS decreases oxidative stress, pro-inflammatory cytokines (TNF-α, IL-1α, IL-1β and IL-6) and apoptosis (Bax/Bcl2 and cleaved caspase-3) in the CI-AKI model. Additionally, RS alleviated mitochondrial damage, as evidenced by morphological changes, are restored ATP synthesis. Furthermore, RS administration resulted in a decrease in mitochondrial fission marker (Drp1) that was increased in the CI-AKI model, while the mitochondrial fusion marker (Mfn2) increased, indicating a restoration of mitochondrial dynamics. Decreased relative blood volume, as evaluated on computed tomography (CT), significantly increased compared to the CI-AKI group after RS administration. Finally, renal injury markers such as Kim-1, Ngal, IL-18 also decreased and kidney function was preserved with RS. These results suggested that RS can mitigate the deterioration of renal function in CI-AKI model.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfBIOCHEMICAL PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcute Kidney Injury* / chemically induced-
dc.subject.MESHAcute Kidney Injury* / prevention & control-
dc.subject.MESHAdenoviridae-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis-
dc.subject.MESHCytokines-
dc.subject.MESHMice-
dc.subject.MESHOxidative Stress*-
dc.titleDelivery of recombinant sestrin2 ameliorates oxidative stress, mitochondrial damage and renal dysfunction in contrast-induced acute kidney injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHyewon Oh-
dc.contributor.googleauthorJe Sung You-
dc.contributor.googleauthorHeejin Bae-
dc.contributor.googleauthorGa Bin Park-
dc.contributor.googleauthorYong Eun Chung-
dc.identifier.doi10.1016/j.bcp.2023.115761-
dc.contributor.localIdA05346-
dc.contributor.localIdA02507-
dc.contributor.localIdA03662-
dc.relation.journalcodeJ00283-
dc.identifier.eissn1873-2968-
dc.identifier.pmid37604294-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006295223003520-
dc.subject.keywordpoptosis-
dc.subject.keywordContrast-induced acute kidney injury-
dc.subject.keywordMitochondrial damage-
dc.subject.keywordOxidative stress-
dc.subject.keywordSestrin2-
dc.contributor.alternativeNameBae, Heejin-
dc.contributor.affiliatedAuthor배희진-
dc.contributor.affiliatedAuthor유제성-
dc.contributor.affiliatedAuthor정용은-
dc.citation.volume215-
dc.citation.startPage115761-
dc.identifier.bibliographicCitationBIOCHEMICAL PHARMACOLOGY, Vol.215 : 115761, 2023-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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