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Preliminary study for prediction of benign vertebral compression fracture age by quantitative water fraction using modified Dixon sequences: an imaging biomarker of fracture age

Authors
 Ja Ho Koo  ;  Joohee Lee  ;  Kyunghwa Han  ;  Ho-Taek Song  ;  Leeha Ryu  ;  Young Han Lee 
Citation
 RADIOLOGIA MEDICA, Vol.128(8) : 970-977, 2023-08 
Journal Title
RADIOLOGIA MEDICA
ISSN
 0033-8362 
Issue Date
2023-08
MeSH
Bone Diseases, Metabolic* ; Bone Marrow Diseases* ; Fractures, Compression* / diagnostic imaging ; Humans ; Magnetic Resonance Imaging / methods ; Retrospective Studies ; Spinal Fractures* / diagnostic imaging
Keywords
Compression fracture ; Fracture age ; Modified Dixon ; Water fraction
Abstract
Purpose: This study aimed to evaluate whether quantitative water fraction parameters could predict fracture age in patients with benign vertebral compression fractures (VCFs).

Methods: A total of 38 thoracolumbar VCFs in 27 patients imaged using modified Dixon sequences for water fraction quantification on 3-T MRI were retrospectively reviewed. To calculate quantitative parameters, a radiologist independently measured the regions of interest in the bone marrow edema (BME) of the fractures. Furthermore, five features (BME, trabecular fracture line, condensation band, cortical or end plate fracture line, and paravertebral soft-tissue change) were analyzed. The fracture age was evaluated based on clear-onset symptoms and previously available images. A correlation analysis between the fracture age and water fraction was evaluated using a linear regression model, and a multivariable analysis of the dichotomized fracture age model was performed.

Results: The water fraction ratio was the only significant factor and was negatively correlated with the fracture age of VCFs in multiple linear regression (p = 0.047), whereas the water fraction was not significantly correlated (p = 0.052). Water fraction and water fraction ratio were significant factors in differentiating the fracture age of 1 year in multiple logistic regression (odds ratio 0.894, p = 0.003 and odds ratio 0.986, p = 0.019, respectively). Using a cutoff of 0.524 for the water fraction, the area under the curve, sensitivity, and specificity were 0.857, 85.7%, and 87.1%, respectively.

Conclusions: Water fraction is a good imaging biomarker for the fracture healing process. The water fraction ratio of the compression fractures can be used to predict the fracture age of benign VCFs.
Full Text
https://link.springer.com/article/10.1007/s11547-023-01662-1
DOI
10.1007/s11547-023-01662-1
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Lee, Joohee(이주희) ORCID logo https://orcid.org/0000-0002-7721-8935
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196243
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