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Association between triglyceride-glucose index and low-density lipoprotein particle size in korean obese adults

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dc.contributor.author송유현-
dc.contributor.author이지원-
dc.contributor.author인요한-
dc.date.accessioned2023-08-09T07:05:59Z-
dc.date.available2023-08-09T07:05:59Z-
dc.date.issued2023-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196051-
dc.description.abstractBackground: Small dense low-density lipoprotein cholesterol (sdLDL-C) is the lipoprotein marker among the various lipoproteins that is most strongly related to atherosclerosis. Insulin resistance (IR) can alter lipid metabolism, and sdLDL-C is characteristic of diabetic dyslipidemia. Therefore, this study sought to inspect the relationship between the triglyceride-glucose (TyG) index and mean low-density lipoprotein (LDL) particle size. Methods: In this study, a total of 128 adults participated. The correlation coefficients between various lipoproteins and the TyG index were compared using Steiger's Z test and the Spearman correlation. The independent link between the TyG index and mean LDL particle size was demonstrated by multiple linear regression analysis. To identify the TyG index cutoff value for the predominance of sdLDL particles, receiver operating characteristic curves were plotted. Results: Mean LDL particle size correlated more strongly with the TyG index than did very low-density lipoprotein, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Regression analysis demonstrated that mean LDL particle size had a strong association with the TyG index (β coefficient = -0.038, P-value < 0.001). The TyG index optimal cutoff value for sdLDL particle predominance and the corresponding area under the curve (standard error: 0.028, 95% confidence interval: 0.842-0.952) were 8.72 and 0.897, respectively, which were close to the cutoff value of diabetes risk in Koreans. Conclusions: Mean LDL particle size is more strongly correlated with the TyG index than do other lipid parameters. After correcting for confounding variables, mean LDL particle size is independently linked with the TyG index. The study indicates that the TyG index is strongly related to atherogenic sdLDL particles predominance.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfLIPIDS IN HEALTH AND DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAtherosclerosis*-
dc.subject.MESHCholesterol, LDL-
dc.subject.MESHGlucose-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHLipoproteins-
dc.subject.MESHObesity-
dc.subject.MESHParticle Size-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHTriglycerides-
dc.titleAssociation between triglyceride-glucose index and low-density lipoprotein particle size in korean obese adults-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentGangnam Severance Hospital (강남세브란스병원)-
dc.contributor.googleauthorSanghoon Kim-
dc.contributor.googleauthorJi-Won Lee-
dc.contributor.googleauthorYaeji Lee-
dc.contributor.googleauthorYouhyun Song-
dc.contributor.googleauthorJohn A Linton-
dc.identifier.doi10.1186/s12944-023-01857-5-
dc.contributor.localIdA05650-
dc.contributor.localIdA03203-
dc.contributor.localIdA03352-
dc.relation.journalcodeJ02169-
dc.identifier.eissn1476-511X-
dc.identifier.pmid37403101-
dc.subject.keywordAtherogenic lipoprotein parameter-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordCardiovascular disease-
dc.subject.keywordDiabetic dyslipidemia-
dc.subject.keywordInsulin resistance-
dc.subject.keywordLow-density lipoprotein subfractions-
dc.subject.keywordSmall dense low-density lipoprotein cholesterol-
dc.subject.keywordTriglyceride-glucose index-
dc.contributor.alternativeNameSong, Youhyun-
dc.contributor.affiliatedAuthor송유현-
dc.contributor.affiliatedAuthor이지원-
dc.contributor.affiliatedAuthor인요한-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage94-
dc.identifier.bibliographicCitationLIPIDS IN HEALTH AND DISEASE, Vol.22(1) : 94, 2023-07-
Appears in Collections:
6. Others (기타) > Others (기타) > 1. Journal Papers
6. Others (기타) > International Health Care Center (국제진료소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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