Cited 18 times in

Early-onset mild cognitive impairment in Parkinson's disease: Altered corticopetal cholinergic network

Authors
 Injoong Kim  ;  Na-Young Shin  ;  Yunjin Bak  ;  Phil Hyu Lee  ;  Seung-Koo Lee  ;  Soo Mee Lim 
Citation
 SCIENTIFIC REPORTS, Vol.7(1) : 2381, 2017-03 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2017-03
MeSH
Age of Onset ; Aged ; Cholinergic Neurons / pathology ; Cognition / physiology ; Cognitive Dysfunction / diagnostic imaging ; Cognitive Dysfunction / physiopathology* ; Female ; Frontal Lobe / diagnostic imaging ; Frontal Lobe / physiopathology* ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Parietal Lobe / diagnostic imaging ; Parietal Lobe / physiopathology* ; Parkinson Disease / diagnostic imaging ; Parkinson Disease / physiopathology* ; Positron-Emission Tomography ; Prospective Studies ; Substantia Innominata / diagnostic imaging ; Substantia Innominata / physiopathology*
Abstract
Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson's disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, <1 year), 18 patients with a longer duration (PD-MCI-LD, ≥1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed. Compared to PD-IC, the collapsed PD-MCI group showed altered rsFC in the right frontal and bilateral parietal areas. PD-MCI-SD showed rsFC alteration in broader frontal and parietal areas compared to the other groups. Decreased rsFC in the right frontal area was also significantly correlated with shorter disease duration. No significant SI volume change was found between the groups. Altered rsFC between the SI and the frontal and parietal areas might be relevant to cognitive dysfunction in PD. Decreased rsFC between the SI and frontal area might be associated with early-onset MCI, suggesting that cholinergic deficits in the frontal brain areas might play an important role in the acceleration of cognitive decline in PD.
Files in This Item:
T999201740.pdf Download
DOI
10.1038/s41598-017-02420-w
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195887
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links