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Inverse Association between Oxidative Balance Score and Incident Type 2 Diabetes Mellitus

 Yu-Jin Kwon  ;  Hye-Min Park  ;  Jun-Hyuk Lee 
 NUTRIENTS, Vol.15(11) : 2497, 2023-05 
Journal Title
Issue Date
Antioxidants ; Diabetes Mellitus, Type 2* / epidemiology ; Diabetes Mellitus, Type 2* / etiology ; Diabetes Mellitus, Type 2* / prevention & control ; Female ; Humans ; Incidence ; Male ; Oxidative Stress ; Prospective Studies ; Risk Factors
Korean genome ; antioxidant ; epidemiology study ; oxidative balance score ; type 2 diabetes mellitus
Mitigating the risk of type 2 diabetes mellitus (T2DM) can be achieved through the maintenance of a healthy weight, the adoption of a healthy diet, and engaging in regular physical activity. The oxidative balance score (OBS), an integrated measure of pro- and antioxidant exposure conditions, represents an individual's overall oxidative balance status. This study aimed to evaluate the association between OBS and T2DM incidence using data from a large, community-based, prospective cohort study. Data from 7369 participants aged 40-69 years who engaged in the Korean Genome and Epidemiology Study (KoGES) were analyzed. The hazard ratio (HR) and 95% confidence interval (CI) for T2DM incidence of sex-specific OBS tertile groups were calculated using univariable and multivariable Cox proportional hazard regression analyses. During the mean 13.6-year follow-up period, 908 men and 880 women developed T2DM. The fully-adjusted HR (95% CI) for incident T2DM of the middle and highest tertile groups, compared with the referent lowest tertile group, were 0.86 (0.77-1.02) and 0.83 (0.70-0.99) in men and were 0.94 (0.80-1.11) and 0.78 (0.65-0.94) in women, respectively. Individuals with a high OBS are at lower risk for the development of T2DM. This implies that lifestyle modification with more antioxidant properties could be a preventive strategy for T2DM.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo
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