흰쥐에 실험적으로 유발한 간종양의 발견률에 대한 fast spin echo fast multiplanar spoiled gradient recalled영상 및 고식적 스핀에코 T1T2 강조 영상의 비교

Abstract

PURPOSE: To compare the ability of tumor detection and the lesion conspicuity between T1- and T2-weighted fastscanning sequences and T1- and T2-weighted conventional spin echo techniques in MR imaging of hepatic tumors.MATERIALS AND METHOD: hepatic tumors were induced on 13 Sprague-Dawley rats by feeding3'methyl-dimethylethylaminoazobenzene mixed with Miller's III formula for 12 weeks. MR images were obtained with1.5T magnet with dual TMJ coil(Signa, GE Medical Systems, Milwaukee, USA). Animals were anesthesized with 150mg/kgof ketamine hydrochloride. T2 weighted fast spin echo(FSE), conventional spin echo(CSE) T2- and T1W1, fastmultiplanar spoiled gradient recalled(FMPSPGR) imaging were obtained. Number of detected tumors andcontrast-to-noise ratio of the tumors were compared for each sequence. RESULTS: Overall 110 tumors were developed.75% of the tumors were detected on FSE, 65% on FMPSPGR, 41% on conventional T2WI, and 41% on T!WI images. Fortumors more than 5mm in diameter, sensitivity was 88% on FMPSPGE, 65% on conventional T2WI, and 81% on T1WI imagesrespectively. CNR of the tumor was 28.94 +- 21.6 on FSE, 13.57 +- 8.64 on FMPSPGR, 12.62 +- 10.65 on CSE T2WI, and9.47 +- 8.05 on CSE T1WI images, which was significantly high on FSE (p<0.005). CONCLUSION:Fast spin echo T2 WIshows highest sensitivity and tumor-to-liver contrast. FMPSPGE imaging is also favorably comparable withconventional T1WI. Therfore these two pulse sequences can be useful in clinical condition for hepatic MR imaging.