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Comparison of humoral immunogenicity in solid organ transplant recipients after third-dose mRNA vaccine with homologous or heterologous schedules: An observational study

 Ji-Man Kang  ;  Juhan Lee  ;  Kyu Ha Huh  ;  Dong Jin Joo  ;  Jae Geun Lee  ;  Ha Yan Kim  ;  Myeongjee Lee  ;  Inkyung Jung  ;  Min Young Kim  ;  Sinyoung Kim  ;  Younhee Park  ;  Myoung Soo Kim 
 JOURNAL OF CLINICAL VIROLOGY, Vol.159 : 105374, 2023-02 
Journal Title
Issue Date
2019-nCoV Vaccine mRNA-1273 ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19 Vaccines ; COVID-19* / prevention & control ; Humans ; Immunoglobulin G ; Organ Transplantation* ; SARS-CoV-2 ; Transplant Recipients ; Vaccination
COVID-19 vaccine ; Heterologous ; Korea ; Omicron ; Organ transplantation ; SARS-CoV-2 variants
Background: Solid organ transplant recipients (SOTRs) are susceptible to severe coronavirus disease 2019 (COVID-19); however, immunogenicity studies of the Omicron variants per vaccination schedules are still lacking. We examined humoral immunogenicity following third-dose mRNA vaccine administration in Korean SOTRs who received primary COVID-19 vaccine series on homologous or heterologous schedules.

Methods: We recruited SOTRs at Severance Hospital from October 27, 2021, to March 31, 2022. Blood samples were collected between 14 days and 5 months after the second and third mRNA vaccine (BNT162b2 or mRNA-1273) doses. SARS-CoV-2 anti-spike IgG titer was analyzed. The neutralization inhibition rate was analyzed using the surrogate neutralization assay for the wild-type, Delta, and Omicron variants.

Results: No significant differences existed in the SARS-CoV-2 anti-spike IgG positivity rate between the homologous BNT162b2/BNT162b2/BNT162b2 (85%) and other heterologous groups (83% of ChAdOx1/ChAdOx1/BNT162b2, 90% of ChAdOx1/ChAdOx1/mRNA-1273, and 78% of ChAdOx1/BNT162b2/BNT162b2). No significant difference existed in the neutralization inhibition rates between the four groups for wild-type, Delta, and Omicron variants. Median neutralization inhibition rates against the Omicron variant (2-5%) were significantly lower than those against the wild-type (87-97%) and Delta (55-89%) variants (P < 0.001).

Conclusions: Regardless of the schedule, the neutralization inhibition rate against the Omicron variant was poor; therefore, additional preventive measures are required in such high-risk populations.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ji-Man(강지만) ORCID logo https://orcid.org/0000-0002-0678-4964
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Park, Youn Hee(박윤희) ORCID logo https://orcid.org/0000-0001-8458-1495
Lee, Myeongjee(이명지)
Lee, Jae Geun(이재근) ORCID logo https://orcid.org/0000-0002-6722-0257
Lee, Ju Han(이주한)
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
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