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The Role of Age in Subclinical Atherosclerosis in Asian People Living with Human Immunodeficiency Virus

Authors
 Sunghee Park  ;  Se Yoon Park  ;  Eunjung Lee  ;  Tae Hyong Kim  ;  Eunyoung Lee 
Citation
 INFECTION AND CHEMOTHERAPY, Vol.54(2) : 308-315, 2022-06 
Journal Title
INFECTION AND CHEMOTHERAPY
ISSN
 2093-2340 
Issue Date
2022-06
Keywords
Cardiovascular disease ; Carotid intima-media thickness ; Dyslipidemia ; HIV ; Risk factors
Abstract
Background: People living with human immunodeficiency virus (PLHIV) have an increased risk of atherosclerosis and cardiovascular disease, but specific guidance on when to suspect the onset of these diseases is limited.

Materials and methods: We aimed to identify cardiovascular risk factors in PLHIV using carotid intima-media thickness (IMT) through a cross-sectional, retrospective cohort study that enrolled 217 PLHIV who underwent carotid IMT measurement at a teaching hospital in Korea. We compared clinical characteristics between PLHIV with subclinical atherosclerosis and PLHIV with IMT within the normal range, and used a receiver operating characteristic curve to determine the cut-off age for predicting subclinical atherosclerosis.

Results: Among the study population, 115 participants (53.0%) had subclinical atherosclerosis. In logistic regression, age and dyslipidemia were significantly associated with increased carotid IMT even after adjusting for other variables (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 1.06 - 1.15, P <0.001; OR: 3.92, 95% CI: 1.87 - 8.22, P <0.001, respectively). The cut-off age for predicting subclinical atherosclerosis was 39.5 years (area under the curve 0.78, 95% CI: 0.72 - 0.84, P <0.001).

Conclusion: Conventional risk factors including age and dyslipidemia were associated with subclinical atherosclerosis in Asian PLHIV. In particular, Asian PLHIV older than 40 years had an increased risk of subclinical atherosclerosis and may benefit from carotid IMT screening.
Files in This Item:
T202300773.pdf Download
DOI
10.3947/ic.2022.0033
Appears in Collections:
6. Others (기타) > Others (기타) > 1. Journal Papers
Yonsei Authors
Park, Se Yoon(박세윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193200
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