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Transcriptomic Comparison Analysis between Ameloblastoma and AM-1 Cell Line

Authors
 Shujin Li  ;  Dong-Joon Lee  ;  Hyun-Yi Kim  ;  Hidemitsu Harada  ;  Young-Soo Jung  ;  Han-Sung Jung 
Citation
 INTERNATIONAL JOURNAL OF STEM CELLS, Vol.15(4) : 415-421, 2022-11 
Journal Title
INTERNATIONAL JOURNAL OF STEM CELLS
ISSN
 2005-3606 
Issue Date
2022-11
Keywords
AM-1 ; Ameloblastoma ; Collagen ; Extracellular matrix ; Tumor invasiveness
Abstract
Cancer initiation and progression are profoundly along with the crosstalk between cancer cells and the surrounding stroma. Accumulating evidence has shown that the therapy targeting the extracellular matrix (ECM) would regress tumor growth and invasion in the most common carcinomas. However, it remains largely unexplored in several rare tumors like odontogenic tumors. Ameloblastoma (AM) is the representative odontogenic epithelial tumor in the jawbone, and it usually infiltrates into adjacent bone marrow and has unlimited growth capacity and a high potential for recurrence. This study aims to investigate the role of collagen-rich ECM during the invasion of AM. Transcriptomic analysis revealed that ECM- and epithelial-to-mesenchymal transition (EMT)-related genes were up-regulated in AM compared to ameloblastoma cell line, AM-1. Tumoroid forming analysis showed that Collagen-rich ECM is indispensable for AM progression, especially for aggressive growth patterns and collective invasion.
Files in This Item:
T202205810.pdf Download
DOI
10.15283/ijsc22132
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Lee, Dong Joon(이동준) ORCID logo https://orcid.org/0000-0001-6532-9729
Jung, Young Soo(정영수) ORCID logo https://orcid.org/0000-0001-5831-6508
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192800
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