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A nomogram combining clinical factors and biomarkers for predicting the recurrence of high-risk cutaneous squamous cell carcinoma

 Yeongjoo Oh  ;  Zhenlong Zheng  ;  Ki-Yeol Kim  ;  Xiangshu Xu  ;  Meiling Pei  ;  Byungho Oh  ;  Sang Kyem Kim  ;  Kee Yang Chung  ;  Mi Ryung Roh 
 BMC CANCER, Vol.22(1) : 1126, 2022-11 
Journal Title
Issue Date
Biomarkers ; Carcinoma, Squamous Cell* / pathology ; Carcinoma, Squamous Cell* / surgery ; Female ; Humans ; Neoplasm Recurrence, Local / pathology ; Neoplasm Staging ; Nomograms ; Prognosis ; Skin Neoplasms* / pathology ; Skin Neoplasms* / surgery
Biomarkers ; Clinical risk factors ; Combined risk factors ; Cutaneous squamous cell carcinoma ; Nomogram ; Prognosis
Background: Although determining the recurrence of cutaneous squamous cell carcinoma (cSCC) is important, currently suggested systems and single biomarkers have limited power for predicting recurrence.

Objective: In this study, combinations of clinical factors and biomarkers were adapted into a nomogram to construct a powerful risk prediction model.

Methods: The study included 145 cSCC patients treated with Mohs micrographic surgery. Clinical factors were reviewed, and immunohistochemistry was performed using tumor tissue samples. A nomogram was constructed by combining meaningful clinical factors and protein markers.

Results: Among the various factors, four clinical factors (tumor size, organ transplantation history, poor differentiation, and invasion into subcutaneous fat) and two biomarkers (Axin2 and p53) were selected and combined into a nomogram. The concordance index (C-index) of the nomogram for predicting recurrence was 0.809, which was higher than that for the American Joint Committee on Cancer (AJCC) 7th, AJCC 8th, Brigham and Women's Hospital, and Breuninger staging systems in the patient data set.

Conclusion: A nomogram model that included both clinical factors and biomarkers was much more powerful than previous systems for predicting cSCC recurrence.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Kim, Sang Kyum(김상겸) ORCID logo https://orcid.org/0000-0003-0768-9923
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Oh, Byung Ho(오병호) ORCID logo https://orcid.org/0000-0001-9575-5665
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
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