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MAFLD Predicts the Risk of Cardiovascular Disease Better than NAFLD in Asymptomatic Subjects with Health Check-Ups

 Hyoeun Kim  ;  Chan Joo Lee  ;  Sang Hoon Ahn  ;  Kwan Sik Lee  ;  Byoung Kwon Lee  ;  Su Jung Baik  ;  Seung Up Kim 
 DIGESTIVE DISEASES AND SCIENCES, Vol.67(10) : 4919-4928, 2022-10 
Journal Title
Issue Date
Calcium ; Cardiovascular Diseases* / complications ; Cardiovascular Diseases* / diagnosis ; Cardiovascular Diseases* / epidemiology ; Coronary Artery Disease* / complications ; Female ; Humans ; Male ; Non-alcoholic Fatty Liver Disease* / complications ; Non-alcoholic Fatty Liver Disease* / diagnosis ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Obesity / epidemiology ; Retrospective Studies ; Risk Factors
Cardiovascular disease, risk assessment ; Metabolic dysfunction-associated fatty liver disease ; Nonalcoholic fatty liver disease
Background and aim: Metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to compensate for the conventional concept of nonalcoholic fatty liver disease (NAFLD). We investigated the superiority of MAFLD versus NAFLD in predicting the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods: A total of 2,144 subjects without a history of ASCVD, who underwent a comprehensive medical health check-up, were selected for the study. The associations between fatty liver status and coronary risk surrogates, such as coronary artery calcium score (CACS), coronary artery disease, quantitative stenosis grade, and 10-year ASCVD risk, were analyzed.

Results: MAFLD and NAFLD were identified in 995 (46.4%) and 891 (41.6%) subjects, respectively. Subjects with MAFLD or NAFLD were more likely to be male and had a significantly higher prevalence of central obesity, obesity, hypertension, diabetes, and dyslipidemia (all, p < 0.05) than their counterparts. In terms of coronary risk surrogates, the MAFLD or NAFLD population had a significantly higher proportion of subjects with CACS > 100, coronary artery disease, higher grade of coronary artery stenosis, and higher 10-year ASCVD risk (all, p < 0.05) than their counterparts. Multivariable logistic regression models showed an independent association between MAFLD/NAFLD and coronary risk surrogates (all, p < 0.05). However, NAFLD only, defined as 'NAFLD, but not MAFLD,' was not associated with an increased coronary risk, compared to MAFLD.

Conclusions: Although both MAFLD and NAFLD discriminated different ASCVD risks, MAFLD predicted the risk of ASCVD better than NAFLD in asymptomatic subjects who underwent medical health check-ups.
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6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hyoeun(김효은) ORCID logo https://orcid.org/0000-0002-7334-9700
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Lee, Jung Il(이정일) ORCID logo https://orcid.org/0000-0002-0142-1398
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
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