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Elevated serum γ-glutamyl transferase is associated with low muscle function in adults independent of muscle mass

Authors
 Seunghyun Lee  ;  Dawon Song  ;  Sungjae Shin  ;  Namki Hong  ;  Yumie Rhee 
Citation
 NUTRITION, Vol.103-104 : 111813, 2022-08 
Journal Title
NUTRITION
ISSN
 0899-9007 
Issue Date
2022-08
MeSH
Adiposity ; Adult ; Female ; Hand Strength* / physiology ; Humans ; Male ; Middle Aged ; Muscles ; Obesity ; gamma-Glutamyltransferase*
Keywords
Handgrip strength ; Hepatic steatosis ; Jump power test ; Muscle function ; Sarcopenia ; γ-glutamyl transferase
Abstract
Objective
Elevated serum γ-glutamyl transferase (GGT), a hepatic cholestasis or liver damage marker, has been associated with low lean mass and adiposity. However, whether serum GGT can predict muscle function in adults remains unclear. The aim of this study was to determine whether an elevated serum GGT is associated with low peak weight-corrected jump power (JP) and low handgrip strength (HGS).

Methods
This study included 662 individuals aged ≥50 y in the final cohort (women, 86%; mean age, 64.8 y). The primary outcome was low peak weight-corrected JP defined as <23.8 W/kg and <19W/kg in men and women, respectively, and the secondary outcome was low HGS (<28 kg in men; <18 kg in women).

Results
Participants with low JP had a higher GGT level, older age, lower HGS, and higher body fat than those without low JP. Serum GGT showed a negative association with JP (adjusted β = –1.16, P = 0.005) and HGS (adjusted β = –0.92, P = 0.018). One log-unit increment in GGT was associated with elevated odds of low JP (adjusted odds ratio [aOR] 2.13, P = 0.002) after adjustment for age, sex, lean mass, and body fat percentage, particularly in individuals without hepatic steatosis (aOR, 2.30) versus those with hepatic steatosis (aOR, 0.80; Pinteraction = 0.020).

Conclusion
Elevated serum GGT was associated with low muscle function in adults independent of age, muscle mass, and adiposity, indicating that serum GGT may play a role as an independent marker of muscle function.
Full Text
https://www.sciencedirect.com/science/article/pii/S089990072200226X?via%3Dihub
DOI
10.1016/j.nut.2022.111813
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191883
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