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Cationic poly(amino acid) surface functionalized manganese nanoparticles for nitric oxide-based immunotherapy and magnetic resonance imaging

Authors
 Jong-Woo Lim  ;  Hye Young Son  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 JOURNAL OF MATERIALS CHEMISTRY B, Vol.10(28) : 5402-5409, 2022-07 
Journal Title
JOURNAL OF MATERIALS CHEMISTRY B
ISSN
 2050-750X 
Issue Date
2022-07
MeSH
Animals ; Biosensing Techniques* ; Electric Impedance ; Humans ; Mice ; Pressure Ulcer* / diagnosis ; Skin ; Textiles ; Amino Acids ; Cations ; Cell Line, Tumor ; Hyaluronic Acid / chemistry ; Immunotherapy ; Magnetic Resonance Imaging ; Manganese ; Manganese Compounds* / chemistry ; Manganese Compounds* / pharmacology ; Nanoparticles* / chemistry ; Nitric Oxide ; Oxides / chemistry ; Oxides / pharmacology
Abstract
The low therapeutic efficacy of conventional cancer chemotherapy has been associated with an immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs), which display an M2-like phenotype, are abundant in many tumors and facilitate tumor growth and resistance to therapy. Here, we show that poly(L-arginine) (PLR), a cationic poly(amino acid) can induce the polarization of macrophages into the tumor-suppressive M1 phenotype, in vitro. Further, we demonstrate that hyaluronic acid (HA) and PLR-coated manganese dioxide (MnO2) nanoparticles (hpMNPs) display efficient anti-cancer effects by upregulating nitric oxide (NO) production. Surface modification with biocompatible HA reduced the cytotoxicity of the cationic PLR. Additionally, manganese ions released from these nanoparticles by the high concentrations of glutathione (GSH) in the TME increased iNOS expression level in macrophages and enhanced the performance of T1 weighted magnetic resonance imaging. Particularly, our results illustrate the therapeutic effects, such as growth inhibition and apoptosis of tumor cells, of hpMNP treated macrophages. Therefore, the newly designed multifunctional PLR-assisted MNPs may facilitate the polarization of M2 macrophages into the M1 phenotype, which can mediate NO-dependent anticancer immunotherapy.
Full Text
https://pubs.rsc.org/en/content/articlelanding/2022/TB/D2TB00794K
DOI
10.1039/D2TB00794K
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191690
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