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Total Lesion Glycolysis on 18F-FDG PET/CT Is a Better Prognostic Factor Than Tumor Dose on 90Y PET/CT in Patients With Hepatocellular Carcinoma Treated With 90Y Transarterial Radioembolization

Authors
 Sang Hyun Hwang  ;  Hye-Suk Hong  ;  Dongwoo Kim  ;  Gyoung Min Kim  ;  Hye Won Lee  ;  Misu Lee  ;  Do Young Kim  ;  Mi-Ae Park  ;  Mijin Yun 
Citation
 CLINICAL NUCLEAR MEDICINE, Vol.47(6) : E437-E443, 2022-06 
Journal Title
CLINICAL NUCLEAR MEDICINE
ISSN
 0363-9762 
Issue Date
2022-06
MeSH
Carcinoma, Hepatocellular* / diagnostic imaging ; Carcinoma, Hepatocellular* / metabolism ; Female ; Fluorodeoxyglucose F18 / metabolism ; Glycolysis ; Humans ; Liver Neoplasms* / diagnostic imaging ; Liver Neoplasms* / metabolism ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Prognosis ; Retrospective Studies ; Tumor Burden ; Yttrium Radioisotopes / therapeutic use
Abstract
Purpose: This study aimed to evaluate the prognostic value of metabolic parameters on 18F-FDG PET/CT and tumor dose (TD) on posttreatment 90Y PET/CT in patients with hepatocellular carcinoma (HCC) who underwent 90Y transarterial radioembolization (TARE).

Patients and methods: Forty-seven HCC patients treated with 90Y TARE were retrospectively enrolled between January 2013 and October 2018. 18F-FDG PET/CT was performed before treatment. Maximum tumor SUV-to-mean normal liver SUV ratio (TLR), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured for each patient. Voxel dosimetry was performed on 90Y PET/CT images to measure TD. The prognostic significance of metabolic parameters on 18F-FDG PET/CT, TD on 90Y PET/CT, and clinical factors for overall survival (OS) was evaluated. In addition, TD on 90Y PET/CT was analyzed in relation to the administered dose of 90Y-labeled microspheres and metabolic parameters on 18F-FDG PET/CT.

Results: The median patient age was 57 years, and 37 patients (78.7%) were men. During the follow-up period, 25 patients (53.2%) died. In univariable analysis, Barcelona Clinic Liver Cancer stage C, Child-Pugh score, TD on 90Y PET/CT, TLR, MTV, and TLG were significant prognostic factors affecting OS (P < 0.05). In multivariable analysis, Barcelona Clinic Liver Cancer stage C and high TLG on 18F-FDG PET/CT were independent prognostic factors for OS (P < 0.05). The 1-year OS rates were 72.9% in patients with low TLG and 33.3% in patients with high TLG (P < 0.05). We also found that TD on 90Y PET/CT was not correlated with the administered dose of 90Y-labeled microspheres, but negatively correlated with TLG on pretreatment 18F-FDG PET/CT (P < 0.05).

Conclusions: TLG, a parameter incorporating both the degree of 18F-FDG uptake and amount of metabolically active tumor volume on pretreatment 18F-FDG PET/CT, is a better prognostic factor than TD on 90Y PET/CT for predicting OS in HCC patients treated with 90Y TARE.
Full Text
https://journals.lww.com/nuclearmed/Fulltext/2022/06000/Total_Lesion_Glycolysis_on_18F_FDG_PET_CT_Is_a.26.aspx
DOI
10.1097/RLU.0000000000004128
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gyoung Min(김경민) ORCID logo https://orcid.org/0000-0001-6768-4396
Kim, Do Young(김도영)
Kim, Dongwoo(김동우) ORCID logo https://orcid.org/0000-0002-1723-604X
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
Hwang, Sang Hyun(황상현) ORCID logo https://orcid.org/0000-0002-8130-6671
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191538
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