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Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium

Authors
 Ara Jo  ;  Jina Won  ;  Chan Hee Gil  ;  Su Keun Kim  ;  Kang-Mu Lee  ;  Sang Sun Yoon  ;  Hyun Jik Kim 
Citation
 NPJ BIOFILMS AND MICROBIOMES, Vol.8(1) : 26, 2022-04 
Journal Title
NPJ BIOFILMS AND MICROBIOMES
ISSN
 * 
Issue Date
2022-04
MeSH
Humans ; Influenza A virus* / physiology ; Interferons ; Nasal Mucosa* / microbiology ; Nasal Mucosa* / virology ; Serine Proteases ; Staphylococcus epidermidis* ; Virus Internalization*
Abstract
Our recent study presented that human nasal commensal Staphylococcus epidermidis could potentiate antiviral immunity in the nasal mucosa through interferon-related innate responses. Here, we found that human nasal commensal S. epidermidis promoted protease-protease inhibitor balance in favor of the host and prevented influenza A virus (IAV) replication in the nasal mucosa and lungs. A relatively higher induction of Serpine1 exhibited in S. epidermidis-inoculated nasal epithelium and S. epidermidis-induced Serpine1 significantly decreased the expression of serine proteases. Furthermore, the transcription of urokinase plasminogen activator (uPA) and Serpine1 was biologically relevant in S. epidermidis-inoculated nasal epithelium, and the induction of uPA might be related to the sequential increase of Serpine1 in human nasal epithelium. Our findings reveal that human nasal commensal S. epidermidis manipulates the cellular environment lacking serine proteases in the nasal epithelium through Serpine1 induction and disturbs IAV spread to the lungs at the level of the nasal mucosa.
Files in This Item:
T202204719.pdf Download
DOI
10.1038/s41522-022-00290-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Lee, Kang Mu(이강무) ORCID logo https://orcid.org/0000-0001-7414-5921
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191368
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