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Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium

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dc.contributor.author윤상선-
dc.contributor.author이강무-
dc.date.accessioned2022-12-22T01:51:44Z-
dc.date.available2022-12-22T01:51:44Z-
dc.date.issued2022-04-
dc.identifier.issn*-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191368-
dc.description.abstractOur recent study presented that human nasal commensal Staphylococcus epidermidis could potentiate antiviral immunity in the nasal mucosa through interferon-related innate responses. Here, we found that human nasal commensal S. epidermidis promoted protease-protease inhibitor balance in favor of the host and prevented influenza A virus (IAV) replication in the nasal mucosa and lungs. A relatively higher induction of Serpine1 exhibited in S. epidermidis-inoculated nasal epithelium and S. epidermidis-induced Serpine1 significantly decreased the expression of serine proteases. Furthermore, the transcription of urokinase plasminogen activator (uPA) and Serpine1 was biologically relevant in S. epidermidis-inoculated nasal epithelium, and the induction of uPA might be related to the sequential increase of Serpine1 in human nasal epithelium. Our findings reveal that human nasal commensal S. epidermidis manipulates the cellular environment lacking serine proteases in the nasal epithelium through Serpine1 induction and disturbs IAV spread to the lungs at the level of the nasal mucosa.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfNPJ BIOFILMS AND MICROBIOMES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHumans-
dc.subject.MESHInfluenza A virus* / physiology-
dc.subject.MESHInterferons-
dc.subject.MESHNasal Mucosa* / microbiology-
dc.subject.MESHNasal Mucosa* / virology-
dc.subject.MESHSerine Proteases-
dc.subject.MESHStaphylococcus epidermidis*-
dc.subject.MESHVirus Internalization*-
dc.titleNasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorAra Jo-
dc.contributor.googleauthorJina Won-
dc.contributor.googleauthorChan Hee Gil-
dc.contributor.googleauthorSu Keun Kim-
dc.contributor.googleauthorKang-Mu Lee-
dc.contributor.googleauthorSang Sun Yoon-
dc.contributor.googleauthorHyun Jik Kim-
dc.identifier.doi10.1038/s41522-022-00290-3-
dc.contributor.localIdA02558-
dc.relation.journalcodeJ04361-
dc.identifier.eissn2055-5008-
dc.identifier.pmid35418111-
dc.contributor.alternativeNameYoon, Sang Sun-
dc.contributor.affiliatedAuthor윤상선-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage26-
dc.identifier.bibliographicCitationNPJ BIOFILMS AND MICROBIOMES, Vol.8(1) : 26, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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