Cited 3 times in

Body CT and PET/CT detection of extracranial lymphoma in patients with newly diagnosed central nervous system lymphoma

 Chong Hyun Suh  ;  Ho Sung Kim  ;  Sung Soo Ahn  ;  Minjung Seong  ;  Kichang Han  ;  Ji Eun Park  ;  Seung Chai Jung  ;  Choong Gon Choi  ;  Sang Joon Kim  ;  Sang Min Lee  ;  Jeong Hoon Kim  ;  Seung-Koo Lee  ;  Seung Hong Choi  ;  Sung Tae Kim  ;  Lakshmi Nayak  ;  Tracy T Batchelor  ;  Raymond Y Huang  ;  Jeffrey P Guenette 
 NEURO-ONCOLOGY, Vol.24(3) : 482-491, 2022-03 
Journal Title
Issue Date
Central Nervous System / pathology ; Cohort Studies ; Fluorodeoxyglucose F18 ; Humans ; Lymphoma* / diagnostic imaging ; Lymphoma* / pathology ; Lymphoma, Large B-Cell, Diffuse* / diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse* / pathology ; Middle Aged ; Positron Emission Tomography Computed Tomography / methods ; Tomography, X-Ray Computed / methods
CT ; Epstein-Barr virus ; PET ; primary central nervous system lymphoma
Background: We aimed to investigate the detection rate of body CT or PET/CT for sites of extracranial disease in patients with a new pathological diagnosis of CNS DLBCL and to identify factors associated with sites of extracranial disease.

Methods: An international multicenter cohort study of consecutive immunocompetent patients with a new diagnosis of CNS DLBCL confirmed by brain biopsy who underwent CT and/or PET/CT to evaluate for sites of extracranial disease between 1998 and 2019. The primary outcome was the detection rate of extracranial lymphoma by CT or PET/CT. Subgroup analyses according to age and EBV status were also performed. Logistic regression analyses were performed to determine factors related to sites of extracranial disease. Detection rates of CT and PET/CT were compared.

Results: One thousand and forty-three patients were included. The overall detection rate of CT or PET/CT was 2.6% (27/1043). The treatment approach was adjusted in 74% of these patients. Multivariable analysis demonstrated that age >61 years (OR, 3.10; P = .016) and EBV positivity (OR, 3.78; P = .045) were associated with greater odds of extracranial lymphoma. There was no statistically significant difference in detection rate between CT and PET/CT (P = .802). In patients ≤61 years old, the false-referral rates were significantly higher than the detection rates (P < .001).

Conclusion: Our results showed increased odds of extracranial lymphoma in patients with older age or EBV-positive lymphoma. Treatment was adjusted in a majority of patients diagnosed with extracranial lymphoma, thereby supporting the current guidelines for the use of contrast-enhanced body CT or PET/CT in patients with newly diagnosed CNS DLBCL.
Files in This Item:
T202204432.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Soo(안성수) ORCID logo
Lee, Seung Koo(이승구) ORCID logo
Han, Ki Chang(한기창) ORCID logo
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.