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Association between the Arylalkylamine N-Acetyltransferase (AANAT) Gene and Seasonality in Patients with Bipolar Disorder

Authors
 So Yung Yang  ;  Kyung Sue Hong  ;  Youngah Cho  ;  Eun-Young Cho  ;  Yujin Choi  ;  Yongkang Kim  ;  Taesung Park  ;  Kyooseob Ha  ;  Ji Hyun Baek 
Citation
 PSYCHIATRY INVESTIGATION, Vol.18(5) : 453-462, 2021-05 
Journal Title
PSYCHIATRY INVESTIGATION
ISSN
 1738-3684 
Issue Date
2021-05
Keywords
AANAT ; Bipolar disorder ; Circadian rhythm ; Melatonin pathway ; Seasonality
Abstract
Objective: Bipolar disorder (BD) is complex genetic disorder. Therefore, approaches using clinical phenotypes such as biological rhythm disruption could be an alternative. In this study, we explored the relationship between melatonin pathway genes with circadian and seasonal rhythms of BD.

Methods: We recruited clinically stable patients with BD (n=324). We measured the seasonal variation of mood and behavior (seasonality), and circadian preference, on a lifetime basis. We analyzed 34 variants in four genes (MTNR1a, MTNR1b, AANAT, ASMT) involved in the melatonin pathway.

Results: Four variants were nominally associated with seasonality and circadian preference. After multiple test corrections, the rs116879618 in AANAT remained significantly associated with seasonality (corrected p=0.0151). When analyzing additional variants of AANAT through imputation, the rs117849139, rs77121614 and rs28936679 (corrected p=0.0086, 0.0154, and 0.0092) also showed a significant association with seasonality.

Conclusion: This is the first study reporting the relationship between variants of AANAT and seasonality in patients with BD. Since AANAT controls the level of melatonin production in accordance with light and darkness, this study suggests that melatonin may be involved in the pathogenesis of BD, which frequently shows a seasonality of behaviors and symptom manifestations.
DOI
10.30773/pi.2020.0436
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190930
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