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Imaging Protocol and Criteria for Evaluation of Axillary Lymph Nodes in the NAUTILUS Trial

Authors
 Jung Min Chang  ;  Hee Jung Shin  ;  Ji Soo Choi  ;  Sung Ui Shin  ;  Bo Hwa Choi  ;  Min Jung Kim  ;  Jung Hyun Yoon  ;  Jin Chung  ;  Tae Hee Kim  ;  Boo-Kyung Han  ;  Hak Hee Kim  ;  Woo Kyung Moon 
Citation
 JOURNAL OF BREAST CANCER, Vol.24(6) : 554-560, 2021-12 
Journal Title
JOURNAL OF BREAST CANCER
ISSN
 1738-6756 
Issue Date
2021-12
MeSH
Breast Neoplasms ; Sentinel Lymph Node Biopsy ; Ultrasonography
Keywords
Axillary ultrasonography (US) is the most commonly used imaging modality for nodal evaluation in patients with breast cancer. No Axillary Surgical Treatment in Clinically Lymph Node-Negative Patients after Ultrasonography (NAUTILUS) is a prospective, multicenter, randomized controlled trial investigating whether sentinel lymph node biopsy (SLNB) can be safely omitted in patients with clinically and sonographically node-negative T1-2 breast cancer treated with breast-conserving therapy. In this trial, a standardized imaging protocol and criteria were established for the evaluation of axillary lymph nodes. Women lacking palpable lymph nodes underwent axillary US to dismiss suspicious nodal involvement. Patients with a round hypoechoic node with effaced hilum or indistinct margins were excluded. Patients with T1 tumors and a single node with a cortical thickness ≥ 3 mm underwent US-guided biopsy. Finally, patients with negative axillary US findings were included. The NAUTILUS axillary US nodal assessment criteria facilitate the proper selection of candidates who can omit SLNB. Trial Registration: ClinicalTrials.gov Identifier: NCT04303715.
Files in This Item:
T202126287.pdf Download
DOI
10.4048/jbc.2021.24.e47
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190672
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