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Au nanozyme-driven antioxidation for preventing frailty

Authors
 Jeonghyo Kim  ;  Sangjin Oh  ;  Yong Cheol Shin  ;  Caifeng Wang  ;  Moon Sung Kang  ;  Jong Ho Lee  ;  Woobin Yun  ;  Jin Ah Cho  ;  Dae Youn Hwang  ;  Dong-Wook Han  ;  Jaebeom Lee 
Citation
 COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.189 : 110839, 2020-05 
Journal Title
COLLOIDS AND SURFACES B-BIOINTERFACES
ISSN
 0927-7765 
Issue Date
2020-05
MeSH
Animals ; Antioxidants / chemistry ; Antioxidants / pharmacology* ; Cell Survival / drug effects ; Cells, Cultured ; Cellular Senescence / drug effects ; Frailty / prevention & control* ; Gallic Acid / chemistry ; Gallic Acid / pharmacology ; Humans ; Isoflavones / chemistry ; Isoflavones / pharmacology ; Male ; Mice ; Mice, Hairless ; Microscopy, Fluorescence ; Organogold Compounds / chemistry ; Organogold Compounds / pharmacology* ; Particle Size ; Surface Properties ; Ultraviolet Rays
Keywords
Phytochemical Au nanoparticle ; Anti-aging ; Frailty ; Senescence ; Nanozyme
Abstract
From senescence and frailty that may result from various biological, mechanical, nutritional, and metabolic processes, the human body has its own antioxidant defense enzymes to remove by-products of oxygen metabolism, and if unregulated, can cause several types of cell damage. Herein, an antioxidant, artificial nanoscale enzyme, called nanozyme (NZs), is introduced that is composed of Au nanoparticles (NPs) synthesized with a mixture of two representative phytochemicals, namely, gallic acid (GA) and isoflavone (IF), referred to as GI-Au NZs. Their unique antioxidant and anti-aging effects are monitored using Cell Counting Kit-8 and senescence-associated beta-galactosidase assays on neonatal human dermal fibroblasts (nHDFs). Furthermore, alterations in epidermal thickness and SOD activity are measured under ultraviolet light to investigate the effects of the topical application of NZs on the histological structure and antioxidant activity in hairless mice skin. Then, hepatotoxicity and nephrotoxicity in the hairless mice are monitored. It is concluded that the NZs can effectively prevent serial passage-induced senescence in nHDFs, as well as oxidative stress in mice skin, suggesting a range of strategies to further develop novel therapeutics for acute frailty.
Full Text
https://www.sciencedirect.com/science/article/pii/S0927776520300692
DOI
10.1016/j.colsurfb.2020.110839
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yong Cheol(신용철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190121
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