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Au nanozyme-driven antioxidation for preventing frailty

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dc.contributor.author신용철-
dc.date.accessioned2022-09-06T06:02:14Z-
dc.date.available2022-09-06T06:02:14Z-
dc.date.issued2020-05-
dc.identifier.issn0927-7765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190121-
dc.description.abstractFrom senescence and frailty that may result from various biological, mechanical, nutritional, and metabolic processes, the human body has its own antioxidant defense enzymes to remove by-products of oxygen metabolism, and if unregulated, can cause several types of cell damage. Herein, an antioxidant, artificial nanoscale enzyme, called nanozyme (NZs), is introduced that is composed of Au nanoparticles (NPs) synthesized with a mixture of two representative phytochemicals, namely, gallic acid (GA) and isoflavone (IF), referred to as GI-Au NZs. Their unique antioxidant and anti-aging effects are monitored using Cell Counting Kit-8 and senescence-associated beta-galactosidase assays on neonatal human dermal fibroblasts (nHDFs). Furthermore, alterations in epidermal thickness and SOD activity are measured under ultraviolet light to investigate the effects of the topical application of NZs on the histological structure and antioxidant activity in hairless mice skin. Then, hepatotoxicity and nephrotoxicity in the hairless mice are monitored. It is concluded that the NZs can effectively prevent serial passage-induced senescence in nHDFs, as well as oxidative stress in mice skin, suggesting a range of strategies to further develop novel therapeutics for acute frailty.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants / chemistry-
dc.subject.MESHAntioxidants / pharmacology*-
dc.subject.MESHCell Survival / drug effects-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCellular Senescence / drug effects-
dc.subject.MESHFrailty / prevention & control*-
dc.subject.MESHGallic Acid / chemistry-
dc.subject.MESHGallic Acid / pharmacology-
dc.subject.MESHHumans-
dc.subject.MESHIsoflavones / chemistry-
dc.subject.MESHIsoflavones / pharmacology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Hairless-
dc.subject.MESHMicroscopy, Fluorescence-
dc.subject.MESHOrganogold Compounds / chemistry-
dc.subject.MESHOrganogold Compounds / pharmacology*-
dc.subject.MESHParticle Size-
dc.subject.MESHSurface Properties-
dc.subject.MESHUltraviolet Rays-
dc.titleAu nanozyme-driven antioxidation for preventing frailty-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorJeonghyo Kim-
dc.contributor.googleauthorSangjin Oh-
dc.contributor.googleauthorYong Cheol Shin-
dc.contributor.googleauthorCaifeng Wang-
dc.contributor.googleauthorMoon Sung Kang-
dc.contributor.googleauthorJong Ho Lee-
dc.contributor.googleauthorWoobin Yun-
dc.contributor.googleauthorJin Ah Cho-
dc.contributor.googleauthorDae Youn Hwang-
dc.contributor.googleauthorDong-Wook Han-
dc.contributor.googleauthorJaebeom Lee-
dc.identifier.doi10.1016/j.colsurfb.2020.110839-
dc.contributor.localIdA05832-
dc.relation.journalcodeJ00627-
dc.identifier.eissn1873-4367-
dc.identifier.pmid32036333-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0927776520300692-
dc.subject.keywordPhytochemical Au nanoparticle-
dc.subject.keywordAnti-aging-
dc.subject.keywordFrailty-
dc.subject.keywordSenescence-
dc.subject.keywordNanozyme-
dc.contributor.alternativeNameShin, Yong Cheol-
dc.contributor.affiliatedAuthor신용철-
dc.citation.volume189-
dc.citation.startPage110839-
dc.identifier.bibliographicCitationCOLLOIDS AND SURFACES B-BIOINTERFACES, Vol.189 : 110839, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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