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Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database

Authors
 Seung Won Lee  ;  Youngmok Park  ;  Sol Kim  ;  Eun Ki Chung  ;  Young Ae Kang 
Citation
 BMC PULMONARY MEDICINE, Vol.22(1) : 283, 2022-07 
Journal Title
BMC PULMONARY MEDICINE
Issue Date
2022-07
MeSH
Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous* / complications ; National Health Programs ; Nontuberculous Mycobacteria* ; Republic of Korea / epidemiology ; Young Adult
Keywords
Comorbidities ; Nontuberculous mycobacteria infection ; Respiratory diseases
Abstract
Background: The global prevalence and incidence of nontuberculous mycobacteria (NTM) infection are increasing. However, the prevalence of NTM infection-associated comorbidities remains understudied. Thus, we investigated the comorbidities associated with NTM infection using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) 2.0 database of the National Health Insurance Service (NHIS).

Methods: In this case-control study, patients with NTM infection and controls aged 20-89 years of age were matched 1:4 by sex, age, region, and income. A total of 26 comorbidities were selected based on previous reports and claims data analysis. The distribution of comorbidities was compared between patients with NTM infection and controls by sex and age using logistic regression analysis.

Results: In total, 893 patients (379 men and 514 women) with NTM infection (mean age, 56.1 years) and 3,572 controls (mean age, 55.6 years) were included. The odds ratio for prevalence of respiratory diseases, metabolic diseases, musculoskeletal disorders, gastrointestinal diseases, skin diseases, mental diseases, and neoplasms was significantly higher in patients with NTM infection than in the control group. Among comorbid diseases, the odds ratios (ORs) for the prevalence of the respiratory diseases such as bronchiectasis (OR [95% confidence interval (CI)]: 26.79 [19.69-36.45]) and interstitial pneumonitis (OR [95% CI]: 15.10 [7.15-31.89]) were the highest. No significant differences were observed in NTM infection-related comorbidities between men and women. In the younger age group (20-39 years old), the prevalence of respiratory and systemic diseases such as hypertension and diabetes was higher in the patient group than in the control group.

Conclusions: NTM infection is associated with several respiratory and systemic diseases that should be considered when providing medical care to patients with NTM infection.
Files in This Item:
T202202991.pdf Download
DOI
10.1186/s12890-022-02075-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Sol(김솔)
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
Lee, Seung Won(이승원)
Chung, Eun Ki(정은기)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189564
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