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Healthy lifestyle factors, cardiovascular comorbidities, and the risk of sudden cardiac arrest: A case-control study in Korea

 Jeong Ho Park  ;  Kyoung-Chul Cha  ;  Young Sun Ro  ;  Kyoung Jun Song  ;  Sang Do Shin  ;  Woo Jin Jung  ;  Young-Il Roh  ;  Sang-Chul Kim  ;  Jonghwan Shin  ;  Yeonho You  ;  Ju-Young Hong  ;  Hyun Ho Ryu  ;  Ju Ok Park  ;  Seung Min Park  ;  Su Jin Kim  ;  Mi Jin Lee  ;  Won Young Kim  ;  Gun Tak Lee  ;  Sung Bum Oh  ;  So Young Kim  ;  Sung Oh Hwang  ;  Cardiac Arrest Pursuit Trial with Unique Registration, Epidemiologic Surveillance CAPTURES project investigators 
 RESUSCITATION, Vol.175 : 142-149, 2022-06 
Journal Title
Issue Date
Case-Control Studies ; Death, Sudden, Cardiac* / epidemiology ; Death, Sudden, Cardiac* / etiology ; Healthy Lifestyle ; Heart Arrest* / complications ; Humans ; Republic of Korea / epidemiology ; Risk Factors
Cardiac arrest ; Case-control studies ; Primary prevention ; Risk factors
Aims: We investigated the impact of healthy lifestyle factors and cardiovascular comorbidities for sudden cardiac arrest.

Methods: A case-control study, including patients with sudden cardiac arrest aged 20-79 years and community-based 1:2 matched controls, was conducted from September 2017 to December 2020. All participants completed a structured questionnaire. Using multivariable logistic regression, we assessed cardiovascular comorbidities (diabetes, hypertension, dyslipidaemia, myocardial infarction, congestive heart failure, arrhythmia, and stroke) and healthy lifestyle factors (low red meat consumption, low fish consumption, high fruit consumption, high vegetable consumption, current non-smoking, regular exercise, and adequate sleep duration) as sudden cardiac arrest risk factors.

Results: Among 3027 eligible cases, informed consent was obtained from 949 (31.3%) cases. A total of 1731 controls were enrolled. Cardiovascular comorbidities, except dyslipidaemia, were associated with an increased risk of sudden cardiac arrest, whereas all healthy lifestyle factors were associated with a decreased risk. Relative to patients in the 0-2 healthy lifestyle factors group, the adjusted odds ratio (95% confidence interval) for sudden cardiac arrest was 0.25 (0.16-0.40) in patients with 3 healthy lifestyle factors, 0.08 (0.05-0.13) in patients with 4 healthy lifestyle factors, and 0.04 (0.03-0.06) in patients with over 5 healthy lifestyle factors. When the number of healthy lifestyle factors was analysed as a continuous variable, each additional factor was associated with a significant decrease in the likelihood of sudden cardiac arrest (adjusted odds ratio [95% confidence interval]: 0.41 [0.36-0.46]).

Conclusion: The increased risk of sudden cardiac arrest by cardiovascular comorbidities could be significantly reduced with healthy lifestyle factors.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Ju Young(홍주영) ORCID logo https://orcid.org/0000-0003-3416-3054
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