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Recent trends in opioid prescriptions in Korea from 2002 to 2015 based on the Korean NHIS-NSC cohort

Authors
 Joungyoun Kim  ;  Sang-Jun Shin  ;  Jihyun Yoon  ;  Hyeong-Seop Kim  ;  Jae-Woo Lee  ;  Ye-Seul Kim  ;  Yonghwan Kim  ;  Hyo-Sun You  ;  Hee-Taik Kang 
Citation
 EPIDEMIOLOGY AND HEALTH, Vol.44 : e2022029, 2022-02 
Journal Title
EPIDEMIOLOGY AND HEALTH
Issue Date
2022-02
MeSH
Aged ; Analgesics, Opioid* / therapeutic use ; Drug Prescriptions ; Fentanyl / therapeutic use ; Humans ; National Health Programs ; Oxycodone ; Practice Patterns, Physicians'* ; Prescriptions
Keywords
Analgesics ; Fentanyl ; Hydromorphone ; Morphine ; Opioid ; Oxycodone
Abstract
Objectives: Opioids are prescribed to treat moderate to severe pain. We investigated recent trends in opioid (morphine, oxycodone, fentanyl, and hydromorphone) prescriptions using data from the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2015.

Methods: The morphine milligram equivalent (MME) was calculated to standardize the relative potency of opioids. The number (cases) or amount (MME) of annual opioid prescriptions per 10,000 registrants was computed to analyze trends in opioid prescriptions after age standardization. Joinpoint regression analysis was conducted to calculate the annual percentage change and average annual percentage change (AAPC).

Results: The number (cases) of prescriptions per 10,000 registrants increased from 0.07 in 2002 to 41.23 in 2015 (AAPC, 76.0%; 95% confidence interval [CI], 61.6 to 91.7). The MME per 10,000 registrants increased from 15.06 in 2002 to 40,727.80 in 2015 (AAPC, 103.0%; 95% CI, 78.2 to 131.3). The highest AAPC of prescriptions and MME per 10,000 registrants were observed in the elderly (60-69 years) and in patients treated at general hospitals. Fentanyl prescriptions increased most rapidly among the 4 opioids.

Conclusions: Consumption of opioids greatly increased in Korea over the 14-year study period.
Files in This Item:
T202202895.pdf Download
DOI
10.4178/epih.e2022029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Joungyoun Kim(김정연)
Yoon, Jihyun(윤지현) ORCID logo https://orcid.org/0000-0002-1057-2235
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189532
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