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Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion

Authors
 Shin Hye Noh  ;  Ye Jin Kim  ;  Min Goo Lee 
Citation
 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Vol.10 : 892450, 2022-06 
Journal Title
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Issue Date
2022-06
Keywords
GRASP ; autophagy ; golgi bypass ; multi-vesicular body ; unconventional protein secretion (UPS)
Abstract
Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those associated with the unconventional protein secretion (UPS) pathways remain largely elusive. A pathway with an emerging role in UPS is autophagy. Although originally known as a degradative process for maintaining intracellular homeostasis, recent studies suggest that autophagy has diverse biological roles besides its disposal function and that it is mechanistically involved in the UPS of various secretory cargos including both leaderless soluble and Golgi-bypassing transmembrane proteins. Here, we summarize current knowledge of the autophagy-related UPS pathways, describing and comparing diverse features in the autophagy-related UPS cargos and autophagy machineries utilized in UPS. Additionally, we also suggest potential directions that further research in this field can take.
Files in This Item:
T202202349.pdf Download
DOI
10.3389/fcell.2022.892450
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Noh, Shin Hye(노신혜) ORCID logo https://orcid.org/0000-0003-3118-9240
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189383
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