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Long-Term Regular Use of Low-Dose Aspirin and Neovascular Age-Related Macular Degeneration: National Sample Cohort 2010-2015

 Tyler Hyungtaek Rim  ;  Tae Keun Yoo  ;  Jiyong Kwak  ;  Jihei Sara Lee  ;  Seo Hee Kim  ;  Dong Wook Kim  ;  Sung Soo Kim 
 OPHTHALMOLOGY, Vol.126(2) : 274-282, 2019-02 
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Aged ; Aspirin / administration & dosage* ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Platelet Aggregation Inhibitors / administration & dosage ; Population Surveillance* ; Propensity Score* ; Republic of Korea / epidemiology ; Retrospective Studies ; Risk Factors ; Time Factors ; Visual Acuity ; Wet Macular Degeneration / diagnosis ; Wet Macular Degeneration / drug therapy* ; Wet Macular Degeneration / epidemiology
Purpose: The association between long-term cardioprotective aspirin use and neovascular age-related macular degeneration (AMD) is controversial. This study was undertaken to estimate the risk of neovascular AMD with long-term regular use of low-dose aspirin. Design: Retrospective population-based study, using a nationwide cohort from a variety of clinics and hospitals in South Korea. Participants: Nonregular aspirin users and regular aspirin users under national health insurance, aged >= 45 years, who were followed from 2010 to 2015, were identified. Methods: Incidence per 10 000 person-years for neovascular AMD was estimated. Long-term regular use of low-dose aspirin was defined as sustained intake of >= 100 mg aspirin with >= 1044 days prescription between 2005 and 2009. Nonregular aspirin users included occasional users or nonusers. The analyses included a propensity score-adjusted analysis in a large, randomly selected, unmatched whole cohort (n = 482 613); propensity score-matched analysis in a matched cohort (n = 74 196); and maximally adjusted analysis in the unmatched whole cohort (n = 482 613). Main Outcome Measures: Incidence of newly developed neovascular AMD using the registration code for intractable disease under national health insurance. Results: Incidence of neovascular AMD was 3.5 among nonregular aspirin users and 7.2 among regular aspirin users per 10 000 person-years in the unmatched whole cohort. However, propensity scoreeadjusted analyses revealed no association between aspirin use and neovascular AMD (adjusted hazard ratio [HR], 0.98; 95% confidence interval [CI], 0.73-1.30). Likewise, propensity scoreematched analyses showed no association; incidences of neovascular AMD were 7.5 and 7.1 among nonregular aspirin users and regular aspirin users (crude HR, 0.94; 95% CI, 0.70-1.28), respectively. A maximally adjusted model, including age, sex, income, residential area, and history of 100 randomly selected types of generic drugs, showed no association (adjusted HR, 0.95; 95% CI, 0.71-1.28). Conclusions: Wefound no association between long-term regular use of low-dose aspirin for 5 years and future incidence of neovascular AMD. Thus, this large-scale study suggests that regular, long-term use of low-dose aspirin appears to be safe with respect to the new development of neovascular AMD. (C) 2018 by the American Academy of Ophthalmology
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jiyong(곽지용) ORCID logo https://orcid.org/0000-0002-7738-9136
Kim, Seo Hee(김서희) ORCID logo https://orcid.org/0000-0003-0319-7139
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Lee, Jihei Sara(이지혜)
Rim, Tyler Hyungtaek(임형택)
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