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Long-Term Regular Use of Low-Dose Aspirin and Neovascular Age-Related Macular Degeneration: National Sample Cohort 2010-2015

DC Field Value Language
dc.contributor.author곽지용-
dc.contributor.author김서희-
dc.contributor.author김성수-
dc.contributor.author이지혜-
dc.contributor.author임형택-
dc.date.accessioned2022-08-19T06:29:04Z-
dc.date.available2022-08-19T06:29:04Z-
dc.date.issued2019-02-
dc.identifier.issn0161-6420-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189211-
dc.description.abstractPurpose: The association between long-term cardioprotective aspirin use and neovascular age-related macular degeneration (AMD) is controversial. This study was undertaken to estimate the risk of neovascular AMD with long-term regular use of low-dose aspirin. Design: Retrospective population-based study, using a nationwide cohort from a variety of clinics and hospitals in South Korea. Participants: Nonregular aspirin users and regular aspirin users under national health insurance, aged >= 45 years, who were followed from 2010 to 2015, were identified. Methods: Incidence per 10 000 person-years for neovascular AMD was estimated. Long-term regular use of low-dose aspirin was defined as sustained intake of >= 100 mg aspirin with >= 1044 days prescription between 2005 and 2009. Nonregular aspirin users included occasional users or nonusers. The analyses included a propensity score-adjusted analysis in a large, randomly selected, unmatched whole cohort (n = 482 613); propensity score-matched analysis in a matched cohort (n = 74 196); and maximally adjusted analysis in the unmatched whole cohort (n = 482 613). Main Outcome Measures: Incidence of newly developed neovascular AMD using the registration code for intractable disease under national health insurance. Results: Incidence of neovascular AMD was 3.5 among nonregular aspirin users and 7.2 among regular aspirin users per 10 000 person-years in the unmatched whole cohort. However, propensity scoreeadjusted analyses revealed no association between aspirin use and neovascular AMD (adjusted hazard ratio [HR], 0.98; 95% confidence interval [CI], 0.73-1.30). Likewise, propensity scoreematched analyses showed no association; incidences of neovascular AMD were 7.5 and 7.1 among nonregular aspirin users and regular aspirin users (crude HR, 0.94; 95% CI, 0.70-1.28), respectively. A maximally adjusted model, including age, sex, income, residential area, and history of 100 randomly selected types of generic drugs, showed no association (adjusted HR, 0.95; 95% CI, 0.71-1.28). Conclusions: Wefound no association between long-term regular use of low-dose aspirin for 5 years and future incidence of neovascular AMD. Thus, this large-scale study suggests that regular, long-term use of low-dose aspirin appears to be safe with respect to the new development of neovascular AMD. (C) 2018 by the American Academy of Ophthalmology-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfOPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAspirin / administration & dosage*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlatelet Aggregation Inhibitors / administration & dosage-
dc.subject.MESHPopulation Surveillance*-
dc.subject.MESHPropensity Score*-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHVisual Acuity-
dc.subject.MESHWet Macular Degeneration / diagnosis-
dc.subject.MESHWet Macular Degeneration / drug therapy*-
dc.subject.MESHWet Macular Degeneration / epidemiology-
dc.titleLong-Term Regular Use of Low-Dose Aspirin and Neovascular Age-Related Macular Degeneration: National Sample Cohort 2010-2015-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorTyler Hyungtaek Rim-
dc.contributor.googleauthorTae Keun Yoo-
dc.contributor.googleauthorJiyong Kwak-
dc.contributor.googleauthorJihei Sara Lee-
dc.contributor.googleauthorSeo Hee Kim-
dc.contributor.googleauthorDong Wook Kim-
dc.contributor.googleauthorSung Soo Kim-
dc.identifier.doi10.1016/j.ophtha.2018.09.014-
dc.contributor.localIdA04511-
dc.contributor.localIdA05307-
dc.contributor.localIdA00571-
dc.contributor.localIdA06116-
dc.contributor.localIdA03419-
dc.relation.journalcodeJ02432-
dc.identifier.eissn1549-4713-
dc.identifier.pmid30240791-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0161642018314428-
dc.contributor.alternativeNameKwak, Jiyong-
dc.contributor.affiliatedAuthor곽지용-
dc.contributor.affiliatedAuthor김서희-
dc.contributor.affiliatedAuthor김성수-
dc.contributor.affiliatedAuthor이지혜-
dc.contributor.affiliatedAuthor임형택-
dc.citation.volume126-
dc.citation.number2-
dc.citation.startPage274-
dc.citation.endPage282-
dc.identifier.bibliographicCitationOPHTHALMOLOGY, Vol.126(2) : 274-282, 2019-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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