Cited 21 times in
Long-Term Regular Use of Low-Dose Aspirin and Neovascular Age-Related Macular Degeneration: National Sample Cohort 2010-2015
DC Field | Value | Language |
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dc.contributor.author | 곽지용 | - |
dc.contributor.author | 김서희 | - |
dc.contributor.author | 김성수 | - |
dc.contributor.author | 이지혜 | - |
dc.contributor.author | 임형택 | - |
dc.date.accessioned | 2022-08-19T06:29:04Z | - |
dc.date.available | 2022-08-19T06:29:04Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0161-6420 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189211 | - |
dc.description.abstract | Purpose: The association between long-term cardioprotective aspirin use and neovascular age-related macular degeneration (AMD) is controversial. This study was undertaken to estimate the risk of neovascular AMD with long-term regular use of low-dose aspirin. Design: Retrospective population-based study, using a nationwide cohort from a variety of clinics and hospitals in South Korea. Participants: Nonregular aspirin users and regular aspirin users under national health insurance, aged >= 45 years, who were followed from 2010 to 2015, were identified. Methods: Incidence per 10 000 person-years for neovascular AMD was estimated. Long-term regular use of low-dose aspirin was defined as sustained intake of >= 100 mg aspirin with >= 1044 days prescription between 2005 and 2009. Nonregular aspirin users included occasional users or nonusers. The analyses included a propensity score-adjusted analysis in a large, randomly selected, unmatched whole cohort (n = 482 613); propensity score-matched analysis in a matched cohort (n = 74 196); and maximally adjusted analysis in the unmatched whole cohort (n = 482 613). Main Outcome Measures: Incidence of newly developed neovascular AMD using the registration code for intractable disease under national health insurance. Results: Incidence of neovascular AMD was 3.5 among nonregular aspirin users and 7.2 among regular aspirin users per 10 000 person-years in the unmatched whole cohort. However, propensity scoreeadjusted analyses revealed no association between aspirin use and neovascular AMD (adjusted hazard ratio [HR], 0.98; 95% confidence interval [CI], 0.73-1.30). Likewise, propensity scoreematched analyses showed no association; incidences of neovascular AMD were 7.5 and 7.1 among nonregular aspirin users and regular aspirin users (crude HR, 0.94; 95% CI, 0.70-1.28), respectively. A maximally adjusted model, including age, sex, income, residential area, and history of 100 randomly selected types of generic drugs, showed no association (adjusted HR, 0.95; 95% CI, 0.71-1.28). Conclusions: Wefound no association between long-term regular use of low-dose aspirin for 5 years and future incidence of neovascular AMD. Thus, this large-scale study suggests that regular, long-term use of low-dose aspirin appears to be safe with respect to the new development of neovascular AMD. (C) 2018 by the American Academy of Ophthalmology | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aspirin / administration & dosage* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Platelet Aggregation Inhibitors / administration & dosage | - |
dc.subject.MESH | Population Surveillance* | - |
dc.subject.MESH | Propensity Score* | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Visual Acuity | - |
dc.subject.MESH | Wet Macular Degeneration / diagnosis | - |
dc.subject.MESH | Wet Macular Degeneration / drug therapy* | - |
dc.subject.MESH | Wet Macular Degeneration / epidemiology | - |
dc.title | Long-Term Regular Use of Low-Dose Aspirin and Neovascular Age-Related Macular Degeneration: National Sample Cohort 2010-2015 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Tyler Hyungtaek Rim | - |
dc.contributor.googleauthor | Tae Keun Yoo | - |
dc.contributor.googleauthor | Jiyong Kwak | - |
dc.contributor.googleauthor | Jihei Sara Lee | - |
dc.contributor.googleauthor | Seo Hee Kim | - |
dc.contributor.googleauthor | Dong Wook Kim | - |
dc.contributor.googleauthor | Sung Soo Kim | - |
dc.identifier.doi | 10.1016/j.ophtha.2018.09.014 | - |
dc.contributor.localId | A04511 | - |
dc.contributor.localId | A05307 | - |
dc.contributor.localId | A00571 | - |
dc.contributor.localId | A06116 | - |
dc.contributor.localId | A03419 | - |
dc.relation.journalcode | J02432 | - |
dc.identifier.eissn | 1549-4713 | - |
dc.identifier.pmid | 30240791 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0161642018314428 | - |
dc.contributor.alternativeName | Kwak, Jiyong | - |
dc.contributor.affiliatedAuthor | 곽지용 | - |
dc.contributor.affiliatedAuthor | 김서희 | - |
dc.contributor.affiliatedAuthor | 김성수 | - |
dc.contributor.affiliatedAuthor | 이지혜 | - |
dc.contributor.affiliatedAuthor | 임형택 | - |
dc.citation.volume | 126 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 274 | - |
dc.citation.endPage | 282 | - |
dc.identifier.bibliographicCitation | OPHTHALMOLOGY, Vol.126(2) : 274-282, 2019-02 | - |
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