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Amelioration of obesity-induced diabetes by a novel autophagy enhancer

Authors
 Hyejin Lim  ;  Myung-Shik Lee 
Citation
 CELL STRESS, Vol.2(7) : 181-183, 2018-07 
Journal Title
CELL STRESS
Issue Date
2018-07
Keywords
Ca2+ ; Tfeb ; calcineurin ; lysosome ; phosphatase
Abstract
Autophagy insufficiency due to aging, high-fat injury or genetic predisposition could be a factor in the progression of metabolic syndrome and diabetes. On the other hand, autophagy enhancement may have beneficial metabolic impact on in vivo metabolism of obese subjects. To identify novel, autophagy enhancer small molecules, we screened a chemical library using a Renilla-LC3-based luciferase assay [Lim et al. Nat Commun 9:1438]. Of the >7000 tested substances, one chemical compound, termed MSL (4-(4-fluorophenyl)sulfonyl-5-methylthio-2-phenyloxazole), (i) enhanced autophagic activity through Tfeb activation, (ii) expedited lipid clearance, probably through lipophagy, and (iii) reduced inflammasome activation through amelioration of mitochondrial dysfunction both in vitro and in vivo, leading to improved metabolic profile of mice with genetic or diet-induced obesity.
Files in This Item:
T999201817.pdf Download
DOI
10.15698/cst2018.07.146
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Lee, Myung Shik(이명식) ORCID logo https://orcid.org/0000-0003-3292-1720
Lim, Jung-eun(임정은)
Lim, Hyejin(임혜진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188862
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