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Arterial enhancing local tumor progression detection on CT images using convolutional neural network after hepatocellular carcinoma ablation: a preliminary study

Authors
 Sanghyeok Lim  ;  YiRang Shin  ;  Young Han Lee 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 1754, 2022-02 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-02
MeSH
Ablation Techniques ; Aged ; Arteries / diagnostic imaging ; Carcinoma, Hepatocellular / diagnostic imaging* ; Carcinoma, Hepatocellular / surgery ; Carcinoma, Hepatocellular / therapy ; Female ; Humans ; Liver Neoplasms / diagnostic imaging ; Liver Neoplasms / surgery ; Liver Neoplasms / therapy ; Male ; Middle Aged ; Neural Networks, Computer* ; Predictive Value of Tests ; ROC Curve ; Radiopharmaceuticals ; Retrospective Studies ; Tomography, X-Ray Computed / methods*
Abstract
To evaluate the performance of a deep convolutional neural network (DCNN) in detecting local tumor progression (LTP) after tumor ablation for hepatocellular carcinoma (HCC) on follow-up arterial phase CT images. The DCNN model utilizes three-dimensional (3D) patches extracted from three-channel CT imaging to detect LTP. We built a pipeline to automatically produce a bounding box localization of pathological regions using a 3D-CNN trained for classification. The performance metrics of the 3D-CNN prediction were analyzed in terms of accuracy, sensitivity, specificity, positive predictive value (PPV), area under the receiver operating characteristic curve (AUC), and average precision. We included 34 patients with 49 LTP lesions and randomly selected 40 patients without LTP. A total of 74 patients were randomly divided into three sets: training (n = 48; LTP: no LTP = 21:27), validation (n = 10; 5:5), and test (n = 16; 8:8). When used with the test set (160 LTP positive patches, 640 LTP negative patches), our proposed 3D-CNN classifier demonstrated an accuracy of 97.59%, sensitivity of 96.88%, specificity of 97.65%, and PPV of 91.18%. The AUC and precision-recall curves showed high average precision values of 0.992 and 0.96, respectively. LTP detection on follow-up CT images after tumor ablation for HCC using a DCNN demonstrated high accuracy and incorporated multichannel registration.
Files in This Item:
T202201554.pdf Download
DOI
10.1038/s41598-022-05794-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188841
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