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Nontuberculous mycobacterial infection after lung transplantation: A single-center experience in South Korea

Authors
 Youngmok Park  ;  Nam Eun Kim  ;  Se Hyun Kwak  ;  Moo Suk Park  ;  Su Jin Jeong  ;  Jin Gu Lee  ;  Hyo Chae Paik  ;  Song Yee Kim  ;  Young Ae Kang 
Citation
 JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, Vol.55(1) : 123-129, 2022-02 
Journal Title
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
ISSN
 1684-1182 
Issue Date
2022-02
MeSH
Humans ; Lung Transplantation* / adverse effects ; Male ; Mycobacterium Infections, Nontuberculous* / microbiology ; Mycobacterium avium Complex ; Nontuberculous Mycobacteria ; Republic of Korea / epidemiology ; Retrospective Studies
Keywords
Incidence ; Lung transplantation ; Nontuberculous mycobacteria ; Nontuberculous mycobacterium infection
Abstract
Purpose: Nontuberculous mycobacteria (NTM) infection is an important issue after lung transplantation. However, a large-scale epidemiological study on this issue in Korea is lacking. We aimed to evaluate the epidemiology of NTM infection after lung transplant surgery in Korea.

Methods: Between October 2012 and December 2018, we retrospectively evaluated lung transplant recipients in a referral hospital in South Korea. A total of 215 recipients were enrolled. The median age at transplantation was 56 years (range, 17-75), and 62% were men. Bronchoscopy was performed according to the surveillance protocol and clinical indications. A diagnosis of NTM infection was defined as a positive NTM culture from a bronchial washing, bronchoalveolar lavage sample, or two separate sputum samples. We determined NTM pulmonary disease (NTM-PD) according to the American Thoracic Society/Infectious Disease Society of America 2007 guidelines. The Kaplan-Meier method and log-rank test were used for conditional survival analysis in patients with follow-up of ≥12 months.

Results: Fourteen patients (6.5%) were diagnosed with NTM infection at a median of 11.8 months (range, 0.3-51.4) after transplantation. Nine patients (4.2%) were diagnosed with NTM-PD, and the incidence rate was 1980/100,000 person-years. Mycobacterium abscessus was the most common species causing NTM-PD (66%), followed by M. avium complex (33%). The presence of NTM infection did not influence all-cause mortality among those who underwent follow-up for ≥12 months (N = 133, log-rank P = 0.816).

Conclusion: The incidence of NTM-PD was considerably high among lung-transplant recipients. M. abscessus was the most common causative species of NTM-PD after lung transplantation.
Files in This Item:
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DOI
10.1016/j.jmii.2020.08.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kwak, Se Hyun(곽세현)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Lee, Jin Gu(이진구)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188834
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