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Gold(I)-Catalyzed Intramolecular Hydrothiophenylation of N-Thiophen-3-yl Alkynylamides for Accessing Thieno[3,2-b]pyridine-5(4H)-ones: Development of F-Actin Specific Fluorescent Probes

Authors
 Dan-Bi Sung  ;  Jang Hee Han  ;  Yong-Keon Kim  ;  Bo Hyun Mun  ;  Sol Park  ;  Hyun Seok Kim  ;  Jong Seok Lee 
Citation
 JOURNAL OF ORGANIC CHEMISTRY, Vol.87(7) : 4936-4950, 2022-02 
Journal Title
JOURNAL OF ORGANIC CHEMISTRY
ISSN
 0022-3263 
Issue Date
2022-02
Abstract
Herein, we describe an original synthetic method for a series of fluorescent thieno[3,2-b]pyridine-5(4H)-one derivatives prepared via the gold(I)-catalyzed 6-endo-dig intramolecular hydrothiophenylation process involving N-thiophen-3-yl alkynylamides. The brightness was improved; emission could be tuned, and larger Stokes shifts were recorded. We also designed and synthesized the phalloidin-based fluorescent chemical probes KF-P1 and KF-P2 to realize fluorescent F-actin imaging.
Full Text
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c02923
DOI
10.1021/acs.joc.1c02923
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Seok(김현석) ORCID logo https://orcid.org/0000-0003-4498-8690
Han, Jang Hee(한장희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188804
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