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Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study

Authors
 Sung-Bum Lee  ;  Byoungjin Park  ;  Kyung-Won Hong  ;  Dong-Hyuk Jung 
Citation
 JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, Vol.9(4) : 104, 2022-04 
Journal Title
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
Issue Date
2022-04
Keywords
Koreans ; cohort study ; genome-wide association study ; hypertension ; renin
Abstract
The renin-angiotensin system (RAS) is a crucial regulator of vascular resistance and blood volume in the body. This study aimed to examine the genetic predisposition of the plasma renin concentration influencing future hypertension incidence. Based on the Korean Genome and Epidemiology Cohort dataset, 5211 normotensive individuals at enrollment were observed over 12 years, categorized into the low-renin and high-renin groups. We conducted genome-wide association studies for the total, low-renin, and high-renin groups. Among the significant SNPs, the lead SNPs of each locus were focused on for further interpretation. The effect of genotypes was determined by logistic regression analysis between controls and new-onset hypertension, after adjusting for potential confounding variables. During a mean follow-up period of 7.6 years, 1704 participants (32.7%) developed hypertension. The low-renin group showed more incidence rates of new-onset hypertension (35.3%) than the high-renin group (26.5%). Among 153 SNPs in renin-related gene regions, two SNPs (rs11726091 and rs8137145) showed an association in the high-renin group, four SNPs (rs17038966, rs145286444, rs2118663, and rs12336898) in the low-renin group, and three SNPs (rs1938859, rs7968218, and rs117246401) in the total population. Most significantly, the low-renin SNP rs12336898 in the SPTAN1 gene, closely related to vascular wall remodeling, was associated with the development of hypertension (p-value = 1.3 × 10-6). We found the candidate genetic polymorphisms according to blood renin concentration. Our results might be a valuable indicator for hypertension risk prediction and preventive measure, considering renin concentration with genetic susceptibility.
Files in This Item:
T202201366.pdf Download
DOI
10.3390/jcdd9040104
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Sung-Bum(이성범)
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188502
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